Source:http://linkedlifedata.com/resource/pubmed/id/15992149
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2005-7-4
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| pubmed:abstractText |
The synthetic purine 4-[[3-(1,6 dihydro-6-oxo-9-purin-9-yl)-1-oxypropyl] amino] benzoic acid (AIT-082, Neotrofin, leteprinim potassium) possesses several biological properties of note: it stimulates outgrowth of neurites from PC12 cells and neurones, stimulates synthesis and/or release of neurotrophic factors from astrocytes, enhances nerve fibre regeneration in vivo and enhances of memory in animals and humans. AIT-082 also protects against glutamate neurotoxicity in vitro and in vivo, which has led to successful tests of AIT-082 in animal models of acute central nervous system injury. In such cases, AIT-082 probably functions by both acutely reducing glutamate excitotoxicity and, over a longer period, by enhancing neuronal sprouting and functional recovery.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1744-7658
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
8
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1255-62
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| pubmed:year |
1999
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| pubmed:articleTitle |
AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury.
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| pubmed:affiliation |
Department of Medicine, McMaster University Health Sciences Center, Hamilton, ON L8N 2S1, Canada. mrathbon@fhs.csu.mcmaster
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| pubmed:publicationType |
Journal Article
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