Source:http://linkedlifedata.com/resource/pubmed/id/15988470
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2005-11-18
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pubmed:abstractText |
The brain synaptic vesicular amine transporter SLCA18A2 is a key component for the uptake of monoamines like dopamine or serotonin into vesicles. We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one nicotine-dependent offspring. For the alcohol-dependent sample, we found statistical significant association for two single markers (rs363387, P=0.03; rs363333, P=0.0066) as well as for several haplotypes (minimal P=0.0038). When the sample with alcohol dependence was stratified according to gender, we observed increased association for the male subgroup (rs363387, P=0.0011). None of the markers showed association in the sample of families with nicotine dependence. However, analysis of a combined sample of alcohol and nicotine-dependent families resulted in single markers as well as several haplotypes showing statistical significant association with substance dependence (minimal P=0.0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0893-133X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2263-8
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pubmed:dateRevised |
2011-5-18
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pubmed:meshHeading |
pubmed-meshheading:15988470-Adult,
pubmed-meshheading:15988470-Aged,
pubmed-meshheading:15988470-Alcoholism,
pubmed-meshheading:15988470-DNA,
pubmed-meshheading:15988470-Female,
pubmed-meshheading:15988470-Genetic Markers,
pubmed-meshheading:15988470-Genotype,
pubmed-meshheading:15988470-Haplotypes,
pubmed-meshheading:15988470-Humans,
pubmed-meshheading:15988470-Linkage Disequilibrium,
pubmed-meshheading:15988470-Male,
pubmed-meshheading:15988470-Middle Aged,
pubmed-meshheading:15988470-Polymorphism, Genetic,
pubmed-meshheading:15988470-Psychiatric Status Rating Scales,
pubmed-meshheading:15988470-Sex Characteristics,
pubmed-meshheading:15988470-Tobacco Use Disorder,
pubmed-meshheading:15988470-Vesicular Monoamine Transport Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence.
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pubmed:affiliation |
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia. sschwab@cyllene.uwa.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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