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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-6-30
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pubmed:abstractText |
Several studies suggested a causal link between AML1 gene rearrangements and both radiation-induced acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS). Fifty-three AML samples were analyzed for the presence of AML1 abnormalities using fluorescent in-situ hybridization (FISH) and reverse transcription polymerase chain reaction (RT-PCR). Of these patients, 24 had experienced radiation exposure due to the Chernobyl accident, and 29 were non-irradiated spontaneous AML cases and served as controls. AML1/ETO translocations were found in 9 of 29 spontaneous AML but only in 1 of 24 radiation-associated AML cases. This difference between translocation frequencies is statistically significant in the age-unstratified cohorts (p=0.015). Following age stratification, the difference becomes less pronounced but remains on borderline significance (p=0.053). AML1 mutation status was assessed in 5 clean-up workers at Chernobyl NPP with MDS, or AML following MDS, by direct sequencing of genomic DNA from the coding region (exon 3 through 8). In one patient who developed MDS following an acute radiation syndrome, a hexanucleotide duplication of CGGCAT in exon 8 was found, inserted after base position 1502. Our results suggest that AML1 gene translocations are infrequent in radiation-induced leukemogenesis but are consistent with the idea that radiation may contribute to the development of MDS through AML1 gene mutation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0449-3060
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pubmed:author |
pubmed-author:AbramenkoIrynaI,
pubmed-author:AtkinsonMichaelM,
pubmed-author:BazykaDimitryD,
pubmed-author:BebeshkoVladimirV,
pubmed-author:BilousNadiaN,
pubmed-author:BinkKarinK,
pubmed-author:DmytrenkoIrynaI,
pubmed-author:KlymenkoSergiyS,
pubmed-author:MisurinAndreiA,
pubmed-author:RosemannMichaelM,
pubmed-author:TrottKlausK,
pubmed-author:ZitzelsbergerHorstH
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
249-55
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15988144-Adult,
pubmed-meshheading:15988144-Aged,
pubmed-meshheading:15988144-Causality,
pubmed-meshheading:15988144-Chernobyl Nuclear Accident,
pubmed-meshheading:15988144-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:15988144-DNA Mutational Analysis,
pubmed-meshheading:15988144-DNA-Binding Proteins,
pubmed-meshheading:15988144-Female,
pubmed-meshheading:15988144-Gene Frequency,
pubmed-meshheading:15988144-Humans,
pubmed-meshheading:15988144-Incidence,
pubmed-meshheading:15988144-Leukemia, Myeloid, Acute,
pubmed-meshheading:15988144-Male,
pubmed-meshheading:15988144-Middle Aged,
pubmed-meshheading:15988144-Myelodysplastic Syndromes,
pubmed-meshheading:15988144-Neoplasms, Radiation-Induced,
pubmed-meshheading:15988144-Power Plants,
pubmed-meshheading:15988144-Proto-Oncogene Proteins,
pubmed-meshheading:15988144-Radioactive Hazard Release,
pubmed-meshheading:15988144-Risk Assessment,
pubmed-meshheading:15988144-Risk Factors,
pubmed-meshheading:15988144-Transcription Factors,
pubmed-meshheading:15988144-Translocation, Genetic,
pubmed-meshheading:15988144-Ukraine
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pubmed:year |
2005
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pubmed:articleTitle |
Aml1 gene rearrangements and mutations in radiation-associated acute myeloid leukemia and myelodysplastic syndromes.
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pubmed:affiliation |
Department of Haematology, Research Centre for Radiation Medicine, Kyiv, Ukraine. klymenko_sergiy@yahoo.co.uk
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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