| pubmed-article:15987636 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15987636 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:15987636 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:15987636 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:15987636 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15987636 | lifeskim:mentions | umls-concept:C0348011 | lld:lifeskim |
| pubmed-article:15987636 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:15987636 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:15987636 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:15987636 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:15987636 | pubmed:dateCreated | 2005-7-15 | lld:pubmed |
| pubmed-article:15987636 | pubmed:abstractText | High voltage-activated Ca(2+) channel expression and gating is controlled by their beta subunits. Although the sites of interaction are known at the atomic level, how beta modulates gating remains to be determined. Using a chimeric approach, beta subunit regulation was conferred to a low voltage-activated channel. Regulation was dependent on a rigid linker connecting the alpha(1) interaction domain to IS6. Chimeric channels also revealed a role for IS6 in channel gating. Taken together, these results support a direct coupling model where beta subunits alter movements in IS6 that occur as the channel transits between closed, open, and inactivated states. | lld:pubmed |
| pubmed-article:15987636 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987636 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15987636 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987636 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15987636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987636 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15987636 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15987636 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:15987636 | pubmed:author | pubmed-author:Perez-ReyesEd... | lld:pubmed |
| pubmed-article:15987636 | pubmed:author | pubmed-author:LeeJung-HaJH | lld:pubmed |
| pubmed-article:15987636 | pubmed:author | pubmed-author:MurbartiánJan... | lld:pubmed |
| pubmed-article:15987636 | pubmed:author | pubmed-author:AriasJuan... | lld:pubmed |
| pubmed-article:15987636 | pubmed:author | pubmed-author:VitkoIuliiaI | lld:pubmed |
| pubmed-article:15987636 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15987636 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:15987636 | pubmed:volume | 579 | lld:pubmed |
| pubmed-article:15987636 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15987636 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15987636 | pubmed:pagination | 3907-12 | lld:pubmed |
| pubmed-article:15987636 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15987636 | pubmed:meshHeading | pubmed-meshheading:15987636... | lld:pubmed |
| pubmed-article:15987636 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15987636 | pubmed:articleTitle | Transfer of beta subunit regulation from high to low voltage-gated Ca2+ channels. | lld:pubmed |
| pubmed-article:15987636 | pubmed:affiliation | Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA. | lld:pubmed |
| pubmed-article:15987636 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15987636 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15987636 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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