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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-8-4
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pubmed:abstractText |
Protein sequence motifs are by definition short fragments of conserved amino acids, often associated with a specific function. Accordingly protein sequence profiles derived from multiple sequence alignments provide an alternative description of functional motifs characterizing families of related sequences. Such profiles conveniently reflect functional necessities by pointing out proximity at conserved sequence positions as well as depicting distances at variable positions. Discovering significant conservation characteristics within the variable positions of profiles mirrors group-specific and, in particular, evolutionary features of the underlying sequences.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
164
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15987530-Amino Acid Motifs,
pubmed-meshheading:15987530-Animals,
pubmed-meshheading:15987530-Arabidopsis,
pubmed-meshheading:15987530-Conserved Sequence,
pubmed-meshheading:15987530-Evolution, Molecular,
pubmed-meshheading:15987530-Gene Expression Profiling,
pubmed-meshheading:15987530-Humans,
pubmed-meshheading:15987530-Mice,
pubmed-meshheading:15987530-Murinae,
pubmed-meshheading:15987530-Oryza sativa,
pubmed-meshheading:15987530-Peptide Mapping,
pubmed-meshheading:15987530-Phylogeny,
pubmed-meshheading:15987530-Rats,
pubmed-meshheading:15987530-Saccharomyces cerevisiae,
pubmed-meshheading:15987530-Sequence Alignment,
pubmed-meshheading:15987530-Software,
pubmed-meshheading:15987530-Species Specificity,
pubmed-meshheading:15987530-Zinc Fingers
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pubmed:year |
2005
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pubmed:articleTitle |
Species-specific analysis of protein sequence motifs using mutual information.
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pubmed:affiliation |
Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, D-14424 Potsdam, Germany. hummel@mpimp-golm.mpg.de
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pubmed:publicationType |
Journal Article
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