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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-6-30
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pubmed:abstractText |
Adenosine is a major negative neuromodulator of synaptic activity in the central nervous system and can exert anticonvulsant and neuroprotective effects in many experimental models of epilepsy. Extracellular adenosine can be formed by a membrane-anchored enzyme ecto-5'-nucleotidase. The purposes of this study were to characterize the role of adenosine receptors in modulating status epilepticus (SE) induced by pilocarpine and evaluate its neuroprotective action. Ecto-5'-nucleotidase activity was studied during the different phases of pilocarpine-induced epilepsy in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,3-dipropyl-8-cyclopentylxanthine,
http://linkedlifedata.com/resource/pubmed/chemical/5'-Nucleotidase,
http://linkedlifedata.com/resource/pubmed/chemical/9-chloro-2-(2-furyl)-5-phenylacetyla...,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/N-(1-methyl-2-phenylethyl)adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Pilocarpine,
http://linkedlifedata.com/resource/pubmed/chemical/Purinergic P1 Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P1,
http://linkedlifedata.com/resource/pubmed/chemical/Triazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthines
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pubmed:status |
MEDLINE
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pubmed:issn |
0013-9580
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46 Suppl 5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
166-73
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15987273-5'-Nucleotidase,
pubmed-meshheading:15987273-Adenosine,
pubmed-meshheading:15987273-Animals,
pubmed-meshheading:15987273-Dentate Gyrus,
pubmed-meshheading:15987273-Disease Models, Animal,
pubmed-meshheading:15987273-Epilepsy, Temporal Lobe,
pubmed-meshheading:15987273-Hippocampus,
pubmed-meshheading:15987273-In Situ Nick-End Labeling,
pubmed-meshheading:15987273-Male,
pubmed-meshheading:15987273-Neuronal Plasticity,
pubmed-meshheading:15987273-Neuroprotective Agents,
pubmed-meshheading:15987273-Pilocarpine,
pubmed-meshheading:15987273-Purinergic P1 Receptor Antagonists,
pubmed-meshheading:15987273-Quinazolines,
pubmed-meshheading:15987273-Rats,
pubmed-meshheading:15987273-Rats, Wistar,
pubmed-meshheading:15987273-Receptors, Purinergic P1,
pubmed-meshheading:15987273-Status Epilepticus,
pubmed-meshheading:15987273-Synapses,
pubmed-meshheading:15987273-Triazoles,
pubmed-meshheading:15987273-Xanthines
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pubmed:year |
2005
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pubmed:articleTitle |
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
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pubmed:affiliation |
Departamento de Neurologia e Neurocirurgia, Disc. Neurologia Experimental, SP, Brasil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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