Source:http://linkedlifedata.com/resource/pubmed/id/15986641
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
13
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pubmed:dateCreated |
2005-6-30
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pubmed:abstractText |
A method of fabricating photo-cross-linked hydrogels with gradients of immobilized molecules and crosslinking densities is introduced. Two macromer/initiator solutions are injected into a unique poly(dimethylsiloxane) channel system that produces a prepolymer gradient that is subsequently polymerized into a water-swollen hydrogel with ultraviolet light exposure. The gradient is controlled by the injection flow rate (optimized to 0.3 microL/min per inlet to produce a linear gradient). The technique is investigated both through fabrication of adhesive ligand gradients that modulate spatial distribution of attached endothelial cells and gradients of cross-linking densities that led to unique hydrogel architectures and spatially dependent swelling.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0743-7463
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5153-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15986641-Cell Adhesion,
pubmed-meshheading:15986641-Cells, Cultured,
pubmed-meshheading:15986641-Humans,
pubmed-meshheading:15986641-Hydrogels,
pubmed-meshheading:15986641-Microfluidics,
pubmed-meshheading:15986641-Microscopy, Electron, Scanning,
pubmed-meshheading:15986641-Microscopy, Fluorescence,
pubmed-meshheading:15986641-Photochemistry,
pubmed-meshheading:15986641-Polymers,
pubmed-meshheading:15986641-Spectrometry, Fluorescence
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pubmed:year |
2004
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pubmed:articleTitle |
Fabrication of gradient hydrogels using a microfluidics/photopolymerization process.
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pubmed:publicationType |
Letter,
Research Support, Non-U.S. Gov't
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