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pubmed-article:15986351pubmed:abstractTextRegulatory T cells play an important role in the prevention of autoimmunity and have been shown to be effective in the treatment of experimental colitis, a T cell-mediated and organ-specific disease. We previously demonstrated that intrinsic CD25+ regulatory T cells modulate the severity of collagen-induced arthritis (CIA), which, in contrast to colitis, is a systemic antibody-mediated disease and an accepted model of rheumatoid arthritis. We undertook this study to determine whether regulatory T cells have the potential to be used therapeutically in arthritis.lld:pubmed
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pubmed-article:15986351pubmed:articleTitleEffective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells.lld:pubmed
pubmed-article:15986351pubmed:affiliationLeiden University Medical Center, Leiden, The Netherlands.lld:pubmed
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