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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2005-7-4
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pubmed:abstractText |
Regulatory T cells play an important role in the prevention of autoimmunity and have been shown to be effective in the treatment of experimental colitis, a T cell-mediated and organ-specific disease. We previously demonstrated that intrinsic CD25+ regulatory T cells modulate the severity of collagen-induced arthritis (CIA), which, in contrast to colitis, is a systemic antibody-mediated disease and an accepted model of rheumatoid arthritis. We undertook this study to determine whether regulatory T cells have the potential to be used therapeutically in arthritis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2212-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15986351-Adoptive Transfer,
pubmed-meshheading:15986351-Animals,
pubmed-meshheading:15986351-Antigens, CD4,
pubmed-meshheading:15986351-Arthritis, Experimental,
pubmed-meshheading:15986351-Bone Marrow Transplantation,
pubmed-meshheading:15986351-DNA-Binding Proteins,
pubmed-meshheading:15986351-Disease Models, Animal,
pubmed-meshheading:15986351-Forkhead Transcription Factors,
pubmed-meshheading:15986351-Immunosuppression,
pubmed-meshheading:15986351-Immunotherapy,
pubmed-meshheading:15986351-Mice,
pubmed-meshheading:15986351-RNA, Messenger,
pubmed-meshheading:15986351-Receptors, Interleukin-2,
pubmed-meshheading:15986351-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15986351-Synovial Membrane,
pubmed-meshheading:15986351-T-Lymphocytes
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pubmed:year |
2005
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pubmed:articleTitle |
Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells.
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pubmed:affiliation |
Leiden University Medical Center, Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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