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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-8-9
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pubmed:abstractText |
Apoptosis of vascular endothelial cells plays a central role in angiogenesis and atherosclerosis. This study investigates the molecular mechanisms of endothelial apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) following inhibition of phosphatidylinositol 3-kinase (PI3K). It examines downstream regulation and activation of the extrinsic and intrinsic pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 and FADD-Like Apoptosis...,
http://linkedlifedata.com/resource/pubmed/chemical/CFLAR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, TNF-Related...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNF-Related Apoptosis-Inducing...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF10A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:issn |
1018-1172
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337-47
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15985761-Apoptosis,
pubmed-meshheading:15985761-Apoptosis Regulatory Proteins,
pubmed-meshheading:15985761-CASP8 and FADD-Like Apoptosis Regulating Protein,
pubmed-meshheading:15985761-Cells, Cultured,
pubmed-meshheading:15985761-Chromones,
pubmed-meshheading:15985761-Endothelium, Vascular,
pubmed-meshheading:15985761-Humans,
pubmed-meshheading:15985761-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15985761-Membrane Glycoproteins,
pubmed-meshheading:15985761-Morpholines,
pubmed-meshheading:15985761-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:15985761-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15985761-Proto-Oncogene Proteins,
pubmed-meshheading:15985761-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:15985761-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:15985761-RNA, Small Interfering,
pubmed-meshheading:15985761-Receptors, TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:15985761-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:15985761-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:15985761-Tumor Necrosis Factor-alpha
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pubmed:articleTitle |
TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol 3-kinase/Akt through the short form of cellular FLIP and Bcl-2.
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pubmed:affiliation |
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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