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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-7-4
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pubmed:abstractText |
We tested the efficacy and safety of glutamine (0.6 gm/kg/day) and creatine (5 gm/day) in 50 ambulant boys with Duchenne muscular dystrophy in a 6-month, double-blind, placebo-controlled clinical trial. Drug efficacy was tested by measuring muscle strength manually (34 muscle groups) and quantitatively (10 muscle groups). Timed functional tests, functional parameters, and pulmonary function tests were secondary outcome measures. Although there was no statistically significant effect of either therapy based on manual and quantitative measurements of muscle strength, a disease-modifying effect of creatine in older Duchenne muscular dystrophy and creatine and glutamine in younger Duchenne muscular dystrophy cannot be excluded. Creatine and glutamine were well tolerated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0364-5134
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pubmed:author |
pubmed-author:BertoriniTulioT,
pubmed-author:BuyseGunnarG,
pubmed-author:CINRG Group,
pubmed-author:CarloJoseJ,
pubmed-author:ClemensPaula RPR,
pubmed-author:ConnollyAnne MAM,
pubmed-author:EscolarDiana MDM,
pubmed-author:FlorenceJulaineJ,
pubmed-author:GoemansNathalieN,
pubmed-author:GorniKsenijaK,
pubmed-author:HenricsonErikE,
pubmed-author:HuangJenniferJ,
pubmed-author:IannacconeSusan TST,
pubmed-author:IgarashiMasanoriM,
pubmed-author:LeshnerRobertR,
pubmed-author:MayhewJillJ,
pubmed-author:MayhewThomasT,
pubmed-author:McCarterRobertR,
pubmed-author:NevoYoramY,
pubmed-author:PasqualiLiviaL,
pubmed-author:PatelKantilal MKM,
pubmed-author:PestronkAlanA,
pubmed-author:SubramonyS HSH,
pubmed-author:Tesi-RochaCarolinaC,
pubmed-author:VedanarayananV VVV,
pubmed-author:WesselHenryH
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15984021-Child,
pubmed-meshheading:15984021-Child, Preschool,
pubmed-meshheading:15984021-Creatine,
pubmed-meshheading:15984021-Glutamine,
pubmed-meshheading:15984021-Humans,
pubmed-meshheading:15984021-Male,
pubmed-meshheading:15984021-Muscle, Skeletal,
pubmed-meshheading:15984021-Muscular Dystrophy, Duchenne,
pubmed-meshheading:15984021-Respiratory Function Tests
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pubmed:year |
2005
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pubmed:articleTitle |
CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy.
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pubmed:affiliation |
Children's National Medical Center, George Washington University, Washington, DC, USA. descolar@cnmcresearch.org
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
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