rdf:type |
|
lifeskim:mentions |
umls-concept:C0003591,
umls-concept:C0003595,
umls-concept:C0015295,
umls-concept:C0022658,
umls-concept:C0030705,
umls-concept:C0035647,
umls-concept:C0152035,
umls-concept:C0332307,
umls-concept:C0596690,
umls-concept:C1280500,
umls-concept:C1704675,
umls-concept:C1882417
|
pubmed:issue |
7
|
pubmed:dateCreated |
2005-6-28
|
pubmed:abstractText |
Triglyceride-rich lipoprotein particles may promote the progression of diabetic nephropathy. Patients with diabetic nephropathy have increased plasma triglycerides and reduced activity of hepatic lipase (HL), which hydrolyzes triglycerides. We hypothesized that the HL -514C-->T polymorphism, which reduces HL expression, and its interactions with polymorphisms in apolipoprotein (apo) E and apoC3 increase the risk of diabetic nephropathy.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0149-5992
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
28
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1704-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:15983323-Apolipoprotein C-III,
pubmed-meshheading:15983323-Apolipoproteins C,
pubmed-meshheading:15983323-Case-Control Studies,
pubmed-meshheading:15983323-Chin,
pubmed-meshheading:15983323-Diabetes Mellitus, Type 2,
pubmed-meshheading:15983323-Diabetic Nephropathies,
pubmed-meshheading:15983323-Exons,
pubmed-meshheading:15983323-Female,
pubmed-meshheading:15983323-Genotype,
pubmed-meshheading:15983323-Humans,
pubmed-meshheading:15983323-Lipase,
pubmed-meshheading:15983323-Male,
pubmed-meshheading:15983323-Middle Aged,
pubmed-meshheading:15983323-Polymorphism, Single Nucleotide,
pubmed-meshheading:15983323-Risk Factors,
pubmed-meshheading:15983323-Smoking,
pubmed-meshheading:15983323-Vascular Diseases
|
pubmed:year |
2005
|
pubmed:articleTitle |
Effect of hepatic lipase -514C->T polymorphism and its interactions with apolipoprotein C3 -482C->T and apolipoprotein E exon 4 polymorphisms on the risk of nephropathy in chinese type 2 diabetic patients.
|
pubmed:affiliation |
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|