| pubmed-article:15983228 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C0011860 | lld:lifeskim |
| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C0042333 | lld:lifeskim |
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| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C1540188 | lld:lifeskim |
| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C1540189 | lld:lifeskim |
| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C1373200 | lld:lifeskim |
| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C1705175 | lld:lifeskim |
| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C1882348 | lld:lifeskim |
| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C1705178 | lld:lifeskim |
| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C1705176 | lld:lifeskim |
| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C0580836 | lld:lifeskim |
| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C1546465 | lld:lifeskim |
| pubmed-article:15983228 | lifeskim:mentions | umls-concept:C1705177 | lld:lifeskim |
| pubmed-article:15983228 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15983228 | pubmed:dateCreated | 2005-6-28 | lld:pubmed |
| pubmed-article:15983228 | pubmed:abstractText | Adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2) are newly identified receptors for adiponectin, an adipocytokine with anti-inflammatory and insulin-sensitizing properties. We screened for polymorphisms by performing sequence analysis on all eight exons, splice junctions, and approximately 2 kb of the 5' flanking regions of each receptor. We detected 5 single nucleotide polymorphisms (SNPs) in ADIPOR1 and 16 SNPs in ADIPOR2. We genotyped these SNPs in Amish subjects with type 2 diabetes (n = 137), impaired glucose tolerance (IGT) (n = 139), and normal glucose tolerance (n = 342) to test for association with type 2 diabetes. Three intronic SNPs in ADIPOR1 were significantly associated with type 2 diabetes (P = 0.014-0.007; odds ratio [OR] 1.61-1.65) and in high linkage disequilibrium (r2 = 0.97-1.0). In ADIPOR2, we found that five SNPs delineated one large haplotype block (r2= 0.9-1.0) spanning >98 kb of the gene and promoter region, which was strongly associated with the combined type 2 diabetes/IGT trait (P < or = 0.001; OR 1.64-1.71). To our knowledge, these data provide the first evidence for association between variation in the adiponectin receptors and type 2 diabetes. | lld:pubmed |
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| pubmed-article:15983228 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15983228 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15983228 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15983228 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15983228 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:15983228 | pubmed:author | pubmed-author:WangJianJ | lld:pubmed |
| pubmed-article:15983228 | pubmed:author | pubmed-author:ShuldinerAlan... | lld:pubmed |
| pubmed-article:15983228 | pubmed:author | pubmed-author:PollinToni... | lld:pubmed |
| pubmed-article:15983228 | pubmed:author | pubmed-author:DamcottColeen... | lld:pubmed |
| pubmed-article:15983228 | pubmed:author | pubmed-author:MitchellBraxt... | lld:pubmed |
| pubmed-article:15983228 | pubmed:author | pubmed-author:OttSandra HSH | lld:pubmed |
| pubmed-article:15983228 | pubmed:author | pubmed-author:ReinhartLauri... | lld:pubmed |
| pubmed-article:15983228 | pubmed:author | pubmed-author:O'connellJeff... | lld:pubmed |
| pubmed-article:15983228 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15983228 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:15983228 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15983228 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15983228 | pubmed:pagination | 2245-50 | lld:pubmed |
| pubmed-article:15983228 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15983228 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15983228 | pubmed:articleTitle | Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. | lld:pubmed |
| pubmed-article:15983228 | pubmed:affiliation | Division of Endocrinology, Diabetesand Nutrition, University of Maryland School of Medicine, 660 West Redwood St., Room 494, Baltimore, MD 21201, USA. | lld:pubmed |
| pubmed-article:15983228 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15983228 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15983228 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15983228 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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