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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011860,
umls-concept:C0042333,
umls-concept:C0238622,
umls-concept:C0332281,
umls-concept:C0332307,
umls-concept:C0580836,
umls-concept:C1373200,
umls-concept:C1540188,
umls-concept:C1540189,
umls-concept:C1546465,
umls-concept:C1705175,
umls-concept:C1705176,
umls-concept:C1705177,
umls-concept:C1705178,
umls-concept:C1882348
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|
pubmed:issue |
7
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|
pubmed:dateCreated |
2005-6-28
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pubmed:abstractText |
Adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2) are newly identified receptors for adiponectin, an adipocytokine with anti-inflammatory and insulin-sensitizing properties. We screened for polymorphisms by performing sequence analysis on all eight exons, splice junctions, and approximately 2 kb of the 5' flanking regions of each receptor. We detected 5 single nucleotide polymorphisms (SNPs) in ADIPOR1 and 16 SNPs in ADIPOR2. We genotyped these SNPs in Amish subjects with type 2 diabetes (n = 137), impaired glucose tolerance (IGT) (n = 139), and normal glucose tolerance (n = 342) to test for association with type 2 diabetes. Three intronic SNPs in ADIPOR1 were significantly associated with type 2 diabetes (P = 0.014-0.007; odds ratio [OR] 1.61-1.65) and in high linkage disequilibrium (r2 = 0.97-1.0). In ADIPOR2, we found that five SNPs delineated one large haplotype block (r2= 0.9-1.0) spanning >98 kb of the gene and promoter region, which was strongly associated with the combined type 2 diabetes/IGT trait (P < or = 0.001; OR 1.64-1.71). To our knowledge, these data provide the first evidence for association between variation in the adiponectin receptors and type 2 diabetes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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|
pubmed:issn |
0012-1797
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2245-50
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15983228-Aged,
pubmed-meshheading:15983228-Blood Glucose,
pubmed-meshheading:15983228-Diabetes Mellitus, Type 2,
pubmed-meshheading:15983228-Ethnic Groups,
pubmed-meshheading:15983228-European Continental Ancestry Group,
pubmed-meshheading:15983228-Exons,
pubmed-meshheading:15983228-Gene Frequency,
pubmed-meshheading:15983228-Genetic Variation,
pubmed-meshheading:15983228-Genotype,
pubmed-meshheading:15983228-Glucose Intolerance,
pubmed-meshheading:15983228-Humans,
pubmed-meshheading:15983228-Introns,
pubmed-meshheading:15983228-Linkage Disequilibrium,
pubmed-meshheading:15983228-Middle Aged,
pubmed-meshheading:15983228-Polymorphism, Single Nucleotide,
pubmed-meshheading:15983228-Promoter Regions, Genetic,
pubmed-meshheading:15983228-Receptors, Adiponectin,
pubmed-meshheading:15983228-Receptors, Cell Surface,
pubmed-meshheading:15983228-Reference Values
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pubmed:year |
2005
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pubmed:articleTitle |
Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.
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pubmed:affiliation |
Division of Endocrinology, Diabetesand Nutrition, University of Maryland School of Medicine, 660 West Redwood St., Room 494, Baltimore, MD 21201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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