rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
2005-6-28
|
pubmed:abstractText |
Adjuvant activities of granulocyte-macrophage colony-stimulating factor (GM-CSF) and synthetic glucosaminyl-muramyl dipeptide (GMDP) were studied in immunization against type 1 herpes simplex virus (HSV1). Gene encoding the gD HSV1 protein (pDNAgD) was used as an immunogen. Gene encoding GM-CSF in pDNAGM-CSF plasmid, which was developed for eukaryotic expression, and GM-DP were used as immune response modulators. GMDP and plasmid DNA with inserted GM-CSF gene enhanced T-cell immune response to HSV1 after a single injection (pDNAGM-CSF) or 24 h before (GMDP) immunization with the gD HSV1 gene. Both adjuvants increased protective effect of DNA-immunization by a virus gene with 63 up to 100% after injection of two genes and up to 96% after the viral gene was inoculated 24 h after GMDP. These high effects indicate that further investigation of anti-HSV1 DNA-based vaccines used with genetic and peptide adjuvant is prospective.
|
pubmed:language |
rus
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0026-8984
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
39
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
504-12
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:15981580-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:15981580-Adjuvants, Immunologic,
pubmed-meshheading:15981580-Animals,
pubmed-meshheading:15981580-Cercopithecus aethiops,
pubmed-meshheading:15981580-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:15981580-Herpesviridae Infections,
pubmed-meshheading:15981580-Herpesvirus 1, Human,
pubmed-meshheading:15981580-Immunity, Cellular,
pubmed-meshheading:15981580-Immunization,
pubmed-meshheading:15981580-Mice,
pubmed-meshheading:15981580-Mice, Inbred BALB C,
pubmed-meshheading:15981580-Vaccines, DNA,
pubmed-meshheading:15981580-Vero Cells,
pubmed-meshheading:15981580-Viral Envelope Proteins,
pubmed-meshheading:15981580-Viral Vaccines
|
pubmed:articleTitle |
[Comparison of adjuvant activities of glucosaminyl-muramyl dipeptide and of the gene coding for granulocyte-macrophage colony-stimulating factor in DNA immunization against herpes simplex virus].
|
pubmed:publicationType |
Journal Article,
English Abstract
|