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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2005-6-27
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pubmed:abstractText |
The ability to maximize bactericidal activity while minimizing toxicity is a therapeutic goal in the treatment of infective endocarditis. We evaluated the impact of administering short-course regimens of gentamicin in combination with daptomycin or vancomycin against one methicillin-susceptible (MSSA 1199) and one methicillin-resistant (MRSA 494) Staphylococcus aureus isolate using an in vitro pharmacodynamic model with simulated endocardial vegetations over 96 h. Human therapeutic dosing regimens for daptomycin (6 and 8 mg/kg of body weight), vancomycin, and gentamicin were simulated. Short-course combination regimens involving gentamicin were administered either as a single 5-mg/kg dose or three 1-mg/kg doses for only the first 24 h and compared to the regimens administered for the full 96-h duration. For all experiments, physiologic conditions of albumin, calcium, and pH were simulated. Both regimens of daptomycin achieved 99.9% kill by 32 h and maintained bactericidal activity against both isolates, which was significantly different from vancomycin, which displayed bacteriostatic activity (P < 0.05). The effects of all short-course regimens of gentamicin were equal to those of the full-duration regimens in combination with daptomycin. Adding three doses of gentamicin (1 mg/kg) to daptomycin resulted in enhancement and bactericidal activity at 24 h against both MRSA and MSSA. The addition of a single dose of gentamicin (5 mg/kg) enhanced or improved the activity of daptomycin and resulted in early bactericidal activity at 4 h against both isolates. The addition of three doses of gentamicin (1 mg/kg) did not improve the activity of vancomycin. However, the addition of a single 5-mg/kg dose of gentamicin to vancomycin resulted in early enhancement at 4 h and 99.9% kill at 32 h for MRSA. These results suggest that a single high dose of gentamicin in combination with daptomycin or vancomycin may be of utility to maximize synergistic and bactericidal activity and minimize toxicity. Further investigation is warranted.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-10390201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-11158740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-11181370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-11353654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-11389505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-11581239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-11794152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-11864946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-12121938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-12121940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-12567300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-12594643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-12709345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-1324637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-1336339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-1336344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-14638509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-14693519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-14999632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-15095227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-15150172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-15184410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-15494908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-15561842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-15616309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-1659305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-1929035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-1929043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-2351627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-2393284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-2523432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-3421575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-3429376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-3980323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-434682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-6751182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-7474277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-7811015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-8686718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-871133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-8749624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-8967707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-9046942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-9860802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15980344-9868662
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2735-45
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15980344-Anti-Bacterial Agents,
pubmed-meshheading:15980344-Culture Media,
pubmed-meshheading:15980344-Daptomycin,
pubmed-meshheading:15980344-Drug Therapy, Combination,
pubmed-meshheading:15980344-Endocarditis, Bacterial,
pubmed-meshheading:15980344-Gentamicins,
pubmed-meshheading:15980344-Humans,
pubmed-meshheading:15980344-Methicillin,
pubmed-meshheading:15980344-Methicillin Resistance,
pubmed-meshheading:15980344-Microbial Sensitivity Tests,
pubmed-meshheading:15980344-Models, Biological,
pubmed-meshheading:15980344-Staphylococcus aureus,
pubmed-meshheading:15980344-Vancomycin
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pubmed:year |
2005
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pubmed:articleTitle |
Short-course gentamicin in combination with daptomycin or vancomycin against Staphylococcus aureus in an in vitro pharmacodynamic model with simulated endocardial vegetations.
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pubmed:affiliation |
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, Michigan 48201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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