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pubmed-article:15979782pubmed:abstractTextRecently, we identified the novel protein D-GPCR (Dresden G protein-coupled receptor) which is selectively overexpressed in human prostate cancer (PCa) and belongs to the subfamily of odorant-like orphan GPCRs. Quantification of D-GPCR transcripts in paired malignant and non-malignant prostate tissues of 106 patients with primary PCa by real-time PCR demonstrated a significant up-regulation of this gene in tumor samples. Furthermore, its expression increases with higher tumor stages and grades. The evaluation of D-GPCR expression as a potential molecular tumor marker was performed by receiver-operating characteristic curve (ROC) analysis resulting in an area under the curve (AUC) value of 0.6452. Hence, the evaluation of D-GPCR as possible additive diagnostic tool and putative therapy target appears promising.lld:pubmed
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pubmed-article:15979782pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15979782pubmed:articleTitleTranscript quantification of Dresden G protein-coupled receptor (D-GPCR) in primary prostate cancer tissue pairs.lld:pubmed
pubmed-article:15979782pubmed:affiliationDepartment of Urology, Technical University Dresden, Fetscherstr. 74, D-01307 Dresden, Germany. susanne.fuessel@uniklinikum-dresden.delld:pubmed
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