15979751

Source:http://linkedlifedata.com/resource/pubmed/id/15979751

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012634, umls-concept:C0027901, umls-concept:C0424295
pubmed:issue	1
pubmed:dateCreated	2005-9-5
pubmed:abstractText	Recent reviews of the neurobiology of Attention-Deficit/Hyperactivity Disorder (AD/HD) have concluded that there is no single pathophysiological profile underlying this disorder. Certainly, dysfunctions in the frontal/subcortical pathways that control attention and motor behavior are implicated. However, no diagnostic criteria or behavioral/neuroimaging techniques allow a clear discrimination among subtypes within this disorder, especially when problems with learning are also considered. Two major Quantitative EEG (QEEG) subtypes have been found to characterize AD/HD. Here we review the major findings in the neurophysiology of AD/HD, focusing on QEEG, and briefly present our previous findings using a source localization technique called Variable Resolution Electromagnetic Tomography (VARETA). These two techniques represent a possible objective method to identify specific patterns corresponding to EEG-defined subtypes of AD/HD. We then propose a model representing the distribution of the neural generators in these two major AD/HD subtypes, localized within basal ganglia and right anterior cortical regions, and hippocampal, para-hippocampal and temporal cortical regions, respectively. A comprehensive review of neurochemical, genetic, neuroimaging, pharmacological and neuropsychological evidence in support of this model is then presented. These results indicate the value of the neurophysiological model of AD/HD and support the involvement of different neuroanatomical systems, particularly the dopaminergic pathways.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8406214
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0167-8760
pubmed:author	pubmed-author:ChabotRobert JRJ, pubmed-author:JohnE RoyER, pubmed-author:PrichepLeslieL, pubmed-author:di MicheleFlaviaF
pubmed:issnType	Print
pubmed:volume	58
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	81-93
pubmed:meshHeading	pubmed-meshheading:15979751-Animals, pubmed-meshheading:15979751-Attention Deficit Disorder with Hyperactivity, pubmed-meshheading:15979751-Brain, pubmed-meshheading:15979751-Dopamine, pubmed-meshheading:15979751-Humans
pubmed:year	2005
pubmed:articleTitle	The neurophysiology of attention-deficit/hyperactivity disorder.
pubmed:affiliation	Brain Research Labs, New York University School of Medicine, 27th and 1st Ave., 8th Floor Old Bellevue Admin. Bldg., New York, NY 10016, USA.
pubmed:publicationType	Journal Article, Review