Linked Life Data

15979510

Source:http://linkedlifedata.com/resource/pubmed/id/15979510

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-6-27
pubmed:abstractText
The Golgi complex in mammalian cells is composed of polarized stacks of flattened cisternal membranes. Stacks are connected by tubules forming a reticular network of membranes closely associated with the microtubule-organizing center. While the Golgi structure is important for the efficient processing of secretory cargo, the organization of the mammalian Golgi complex may indicate potential functions in addition to the processing and sorting of cargo. Similar to the endoplasmic reticulum stress response pathway, the Golgi complex may initiate signaling pathways to alleviate stress, and if irreparable, trigger apoptosis. Here, we review recent experimental evidence suggesting that the elaborate structure of the Golgi complex in mammalian cells may have evolved to sense and transduce stress signals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
1744
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
406-14
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Golgi structure in stress sensing and apoptosis.
pubmed:affiliation
Department of Cell Biology, Johns Hopkins University School of Medicine, 725 Wolfe St., Baltimore, MD 21205, United States.
pubmed:publicationType
Journal Article, Review