Linked Life Data

1597746

Source:http://linkedlifedata.com/resource/pubmed/id/1597746

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-7-6
pubmed:abstractText
The distortions inherent in PET images of the human heart due to finite image resolution and cardiac motion limit the capability to evaluate physiology quantitatively. A method based on a simple geometrical model of region of interest representations in physical space has been developed to minimize these distortions. In this paper, simulation studies have been performed to evaluate the noise characteristics of the method. This study demonstrates that unbiased estimates of kinetic model parameters which describe myocardial physiology can be measured with an accuracy of 7%-15% for scale-related parameters and 4%-16% for shape-related parameters of kinetic models in studies with the equivalent of 1 million events. Application of the techniques developed in this paper for the measurement of myocardial blood flow in eight dogs (14 independent flow states) shows a strong correlation with microsphere determined blood flow in the same animals (slope = 1.022, intercept = -0.18, r = 0.96).
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0161-5505
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1243-50
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
A region of interest strategy for minimizing resolution distortions in quantitative myocardial PET studies.
pubmed:affiliation
University of Michigan Medical Center, Department of Internal Medicine, Ann Arbor 48109-0552.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.