| pubmed-article:15976219 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15976219 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15976219 | lifeskim:mentions | umls-concept:C0086439 | lld:lifeskim |
| pubmed-article:15976219 | lifeskim:mentions | umls-concept:C0002932 | lld:lifeskim |
| pubmed-article:15976219 | lifeskim:mentions | umls-concept:C0015131 | lld:lifeskim |
| pubmed-article:15976219 | lifeskim:mentions | umls-concept:C0206518 | lld:lifeskim |
| pubmed-article:15976219 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:15976219 | lifeskim:mentions | umls-concept:C0162735 | lld:lifeskim |
| pubmed-article:15976219 | lifeskim:mentions | umls-concept:C1420841 | lld:lifeskim |
| pubmed-article:15976219 | lifeskim:mentions | umls-concept:C2698300 | lld:lifeskim |
| pubmed-article:15976219 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:15976219 | lifeskim:mentions | umls-concept:C1176027 | lld:lifeskim |
| pubmed-article:15976219 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15976219 | pubmed:dateCreated | 2005-6-24 | lld:pubmed |
| pubmed-article:15976219 | pubmed:abstractText | A photoactivable diazirine derivative of etomidate, azietomidate, shares many actions of etomidate, including a capacity to abolish the righting reflexes in tadpoles and enhance gamma-aminobutyric acid (GABA)-induced currents. Azietomidate's usefulness in studies of mechanisms of anesthesia depends on the assumption that it shares a site of action with etomidate. Mice bearing an N265M beta3 subunit point mutation in GABA(A) receptors have a markedly decreased sensitivity to loss of righting reflexes induced by etomidate over a range of doses. Accordingly, in the present study we measured the time to recovery of righting reflexes of wild type and mutant mice as a function of dose given as an IV bolus. Analysis of the data for azietomidate yielded mean times to recovery of righting reflexes at a dose of 7.5 mg/kg of 10.0 +/- 0.9 min and 3.0 +/- 1.6 min for wild type and mutant mice, respectively (mean +/- sd). A similar analysis for etomidate yielded mean times to recovery of righting reflexes at a dose of 7.5 mg/kg of 12.0 +/- 1.3 min and 4.0 +/- 0.7 min for wild type and mutant mice respectively. Thus, at this dose a single mutation, N265M on the beta3 subunit of the GABA(A) receptor, approximately halved the time to recovery of righting reflexes for both etomidate and azietomidate (by 7.6 +/- 1.5 min and 7.2 +/- 1.8 min, respectively), emphasizing the contribution of this residue as a determinant of a behavioral response of azietomidate in mice. | lld:pubmed |
| pubmed-article:15976219 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15976219 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15976219 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15976219 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15976219 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15976219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15976219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15976219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15976219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15976219 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15976219 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15976219 | pubmed:issn | 0003-2999 | lld:pubmed |
| pubmed-article:15976219 | pubmed:author | pubmed-author:IkeV OVO | lld:pubmed |
| pubmed-article:15976219 | pubmed:author | pubmed-author:EgerEdmond... | lld:pubmed |
| pubmed-article:15976219 | pubmed:author | pubmed-author:RudolphUweU | lld:pubmed |
| pubmed-article:15976219 | pubmed:author | pubmed-author:JurdRachelR | lld:pubmed |
| pubmed-article:15976219 | pubmed:author | pubmed-author:SonnerJames... | lld:pubmed |
| pubmed-article:15976219 | pubmed:author | pubmed-author:HusainS... | lld:pubmed |
| pubmed-article:15976219 | pubmed:author | pubmed-author:MillerKeith... | lld:pubmed |
| pubmed-article:15976219 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15976219 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:15976219 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15976219 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15976219 | pubmed:pagination | 131-5, table of contents | lld:pubmed |
| pubmed-article:15976219 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15976219 | pubmed:meshHeading | pubmed-meshheading:15976219... | lld:pubmed |
| pubmed-article:15976219 | pubmed:meshHeading | pubmed-meshheading:15976219... | lld:pubmed |
| pubmed-article:15976219 | pubmed:meshHeading | pubmed-meshheading:15976219... | lld:pubmed |
| pubmed-article:15976219 | pubmed:meshHeading | pubmed-meshheading:15976219... | lld:pubmed |
| pubmed-article:15976219 | pubmed:meshHeading | pubmed-meshheading:15976219... | lld:pubmed |
| pubmed-article:15976219 | pubmed:meshHeading | pubmed-meshheading:15976219... | lld:pubmed |
| pubmed-article:15976219 | pubmed:meshHeading | pubmed-meshheading:15976219... | lld:pubmed |
| pubmed-article:15976219 | pubmed:meshHeading | pubmed-meshheading:15976219... | lld:pubmed |
| pubmed-article:15976219 | pubmed:meshHeading | pubmed-meshheading:15976219... | lld:pubmed |
| pubmed-article:15976219 | pubmed:meshHeading | pubmed-meshheading:15976219... | lld:pubmed |
| pubmed-article:15976219 | pubmed:meshHeading | pubmed-meshheading:15976219... | lld:pubmed |
| pubmed-article:15976219 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15976219 | pubmed:articleTitle | R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit. | lld:pubmed |
| pubmed-article:15976219 | pubmed:affiliation | Department of Anesthesia and Perioperative Care, S-455, University of California, San Francisco, CA 94143-0464, USA. | lld:pubmed |
| pubmed-article:15976219 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15976219 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15976219 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15976219 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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