|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007595,
umls-concept:C0035339,
umls-concept:C0039562,
umls-concept:C0162638,
umls-concept:C0183683,
umls-concept:C0205296,
umls-concept:C0282549,
umls-concept:C0344211,
umls-concept:C0441655,
umls-concept:C0456387,
umls-concept:C0521390,
umls-concept:C1171411,
umls-concept:C1317973,
umls-concept:C1516044,
umls-concept:C1521721,
umls-concept:C1880355,
umls-concept:C1883254,
umls-concept:C2603343
|
|
pubmed:issue |
13
|
|
pubmed:dateCreated |
2005-6-24
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|
pubmed:abstractText |
New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
pubmed-author:AbbadessaVincenzoV,
pubmed-author:AielloStefaniaS,
pubmed-author:BaruchelloRiccardoR,
pubmed-author:CavalliniSabrinaS,
pubmed-author:CrostaLuciaL,
pubmed-author:Di CristinaAntoniettaA,
pubmed-author:GebbiaNicolaN,
pubmed-author:GianniniGiuseppeG,
pubmed-author:GrimaudoStefaniaS,
pubmed-author:GrisoliaGiuseppinaG,
pubmed-author:InvidiataFrancesco PaoloFP,
pubmed-author:MarinoSilviaS,
pubmed-author:RobertiMarinellaM,
pubmed-author:RondaninRiccardoR,
pubmed-author:RossiMarcelloM,
pubmed-author:SimoniDanieleD,
pubmed-author:SiniscalchiAnnaA,
pubmed-author:TolomeoManlioM
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
30
|
|
pubmed:volume |
48
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4293-9
|
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
|
|
pubmed:year |
2005
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|
pubmed:articleTitle |
Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells.
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|
pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Via Fossato di Mortara 17-19, 44100 Ferrara, Italy. smd@dns.unife.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
