Source:http://linkedlifedata.com/resource/pubmed/id/15973455
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2005-7-21
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| pubmed:abstractText |
Clonally related composite lymphomas of Hodgkin's lymphoma (HL) and Non-Hodgkin's lymphoma (NHL) represent models to study the multistep transformation process in tumorigenesis and the development of two distinct tumors from a shared precursor. We analyzed six such lymphomas for transforming events. The HLs were combined in two cases with follicular lymphoma (FL), and in one case each with B-cell chronic lymphocytic leukemia, splenic marginal zone lymphoma, mantle cell lymphoma (MCL) and diffuse large B-cell lymphoma (DLBCL). In the HL/FL and HL/MCL combinations, BCL2/IGH and CCND1/IGH translocations, respectively, were detected in both the HL and NHL. No mutations were found in the tumor suppressor genes FAS, NFKBIA and ATM. The HL/DLBCL case harbored clonal replacement mutations of the TP53 gene on both alleles exclusively in the DLBCL. In conclusion, we present the first examples of molecularly verified IgH-associated translocations in HL, which also show that BCL2/IGH or CCND1/IGH translocations can represent early steps in the pathogenesis of composite HL/FL or HL/MCL. The restriction of the TP53 mutations to the DLBCL in the HL/DLBCL case exemplifies a late transforming event that presumably happened in the germinal center and affected the fate of a common lymphoma precursor cell towards development of a DLBCL.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0887-6924
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| pubmed:author |
pubmed-author:AustenBB,
pubmed-author:BräuningerAA,
pubmed-author:DistlerVV,
pubmed-author:HansmannM-LML,
pubmed-author:KüppersRR,
pubmed-author:LestaniMM,
pubmed-author:MenestrinaFF,
pubmed-author:RennéCC,
pubmed-author:RosenquistRR,
pubmed-author:SchmitzRR,
pubmed-author:StankovicTT,
pubmed-author:TinguelyMM
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| pubmed:copyrightInfo |
Leukemia (2005) 19, 1452-1458.
|
| pubmed:issnType |
Print
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| pubmed:volume |
19
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1452-8
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15973455-Cell Transformation, Neoplastic,
pubmed-meshheading:15973455-Clone Cells,
pubmed-meshheading:15973455-Cyclin D1,
pubmed-meshheading:15973455-Genes, Tumor Suppressor,
pubmed-meshheading:15973455-Genes, bcl-2,
pubmed-meshheading:15973455-Hodgkin Disease,
pubmed-meshheading:15973455-Humans,
pubmed-meshheading:15973455-Immunoglobulin Heavy Chains,
pubmed-meshheading:15973455-Lymphoma,
pubmed-meshheading:15973455-Lymphoma, Non-Hodgkin,
pubmed-meshheading:15973455-Mutation,
pubmed-meshheading:15973455-Translocation, Genetic,
pubmed-meshheading:15973455-Tumor Suppressor Protein p53
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Insights into the multistep transformation process of lymphomas: IgH-associated translocations and tumor suppressor gene mutations in clonally related composite Hodgkin's and non-Hodgkin's lymphomas.
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| pubmed:affiliation |
Institute for Cell Biology (Tumor Research), University of Duisburg-Essen Medical School, Essen, Germany. roland.schmitz@uni-essen.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|