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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-6-23
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pubmed:abstractText |
Polyclonal B cell activation promotes immunity without the loss of tolerance. Our data show that during activation of the innate immune system, B cell tolerance to Smith Ag Sm is maintained by dendritic cells (DCs) and macrophages (MPhi). TLR4-activated myeloid DCs and MPhi, but not plasmacytoid or lymphoid DCs, repressed autoreactive B cells through the secretion of soluble mediators, including IL-6. Although IL-6 promotes plasma cell differentiation of B cells acutely stimulated by Ag, we show that it repressed cells that were chronically exposed to self-Ag. This mechanism of tolerance was not limited to Smith Ag-specific B cells as hen egg lysozyme- and p-azophenylarsonate-specific B cells were similarly affected. Our data define a tolerogenic role for MPhi and DCs in regulating autoreactive B cells during activation of the innate immune system.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-41
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15972629-Animals,
pubmed-meshheading:15972629-Autoantigens,
pubmed-meshheading:15972629-Autoimmunity,
pubmed-meshheading:15972629-B-Lymphocytes,
pubmed-meshheading:15972629-Dendritic Cells,
pubmed-meshheading:15972629-Immune Tolerance,
pubmed-meshheading:15972629-Immunity, Innate,
pubmed-meshheading:15972629-Interleukin-6,
pubmed-meshheading:15972629-Lymphocyte Activation,
pubmed-meshheading:15972629-Macrophages,
pubmed-meshheading:15972629-Mice,
pubmed-meshheading:15972629-Mice, Inbred A,
pubmed-meshheading:15972629-Mice, Inbred C57BL,
pubmed-meshheading:15972629-Mice, Knockout,
pubmed-meshheading:15972629-Mice, Transgenic,
pubmed-meshheading:15972629-Muramidase,
pubmed-meshheading:15972629-Ribonucleoproteins, Small Nuclear,
pubmed-meshheading:15972629-snRNP Core Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Low-affinity, Smith antigen-specific B cells are tolerized by dendritic cells and macrophages.
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pubmed:affiliation |
Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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