Source:http://linkedlifedata.com/resource/pubmed/id/15972602
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2005-6-23
|
| pubmed:abstractText |
In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated that cognitive impairment constitutes a major predictor of nonsurvival. In the present NONA longitudinal study, we simultaneously examine in a model of allostatic load IRP and compromised cognition in 4-year survival in a population-based sample (n = 138, 86-94 years). Immune system measurements consisted of determinations of T-cell subsets, plasma interleukin 6 and cytomegalovirus and Epstein-Barr virus serology. Interleukin 2 responsiveness to concanavalin A, using data from the previous OCTO (octogenarians) immune study, hereafter OCTO immune, was also examined. Cognitive status was rated using a battery of neuropsychological tests. Logistic regression indicated that the IRP and cognitive impairment together predicted 58% of observed deaths. IRP was associated with late differentiated CD8+CD28-CD27- cells (p < .001), decreased interleukin 2 responsiveness (p < .05) and persistent viral infection (p < .01). Cognitive impairment was associated with increased plasma interleukin 6 (p < .001). IRP individuals with cognitive impairment were all deceased at the follow-up, indicating an allostatic overload.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1079-5006
|
| pubmed:author |
pubmed-author:ErnerudhJanJ,
pubmed-author:FergusonFrederickF,
pubmed-author:ForseyRosalynR,
pubmed-author:JohanssonBooB,
pubmed-author:LöfgrenStureS,
pubmed-author:NilssonBengt-OlofBO,
pubmed-author:PawelecGrahamG,
pubmed-author:StrindhallJanJ,
pubmed-author:ThompsonJulieJ,
pubmed-author:WikbyAndersA
|
| pubmed:issnType |
Print
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
556-65
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15972602-Aged,
pubmed-meshheading:15972602-Aged, 80 and over,
pubmed-meshheading:15972602-Aging,
pubmed-meshheading:15972602-Analysis of Variance,
pubmed-meshheading:15972602-Antigens, CD,
pubmed-meshheading:15972602-CD4-CD8 Ratio,
pubmed-meshheading:15972602-Cognition Disorders,
pubmed-meshheading:15972602-Cohort Studies,
pubmed-meshheading:15972602-Female,
pubmed-meshheading:15972602-Geriatric Assessment,
pubmed-meshheading:15972602-Health Status Indicators,
pubmed-meshheading:15972602-Humans,
pubmed-meshheading:15972602-Immunocompromised Host,
pubmed-meshheading:15972602-Interleukin-2,
pubmed-meshheading:15972602-Interleukin-6,
pubmed-meshheading:15972602-Life Expectancy,
pubmed-meshheading:15972602-Longevity,
pubmed-meshheading:15972602-Longitudinal Studies,
pubmed-meshheading:15972602-Male,
pubmed-meshheading:15972602-Phenotype,
pubmed-meshheading:15972602-Probability,
pubmed-meshheading:15972602-Risk Assessment,
pubmed-meshheading:15972602-Statistics, Nonparametric,
pubmed-meshheading:15972602-Survival Rate,
pubmed-meshheading:15972602-Sweden
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans.
|
| pubmed:affiliation |
Department of Natural Science and Biomedicine, School of Health sciences, Jönköping University, Sweden.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|