Linked Life Data

15971713

Source:http://linkedlifedata.com/resource/pubmed/id/15971713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-6-23
pubmed:abstractText
The objective of this study was to develop a nonlinear and anisotropic three-dimensional mathematical model of tendon behavior in which the structural components of fibers, matrix, and fiber-matrix interactions are explicitly incorporated and to use this model to infer the contributions of these structures to tendon mechanical behavior. We hypothesized that this model would show that: (i) tendon mechanical behavior is not solely governed by the isotropic matrix and fiber stretch, but is also influenced by fiber-matrix interactions; and (ii) shear fiber-matrix interaction terms will better describe tendon mechanical behavior than bulk fiber-matrix interaction terms. Model versions that did and did not include fiber-matrix interaction terms were applied to experimental tendon stress-strain data in longitudinal and transverse orientations, and the R2 goodness-of-fit was evaluated. This study showed that models that included fiber-matrix interaction terms improved the fit to longitudinal data (R2(toe) = 0.88, R2(Lin) = 0.94) over models that only included isotropic matrix and fiber stretch terms (R2(Toe) = 0.36, R2(Lin) = 0.84). Shear fiber-matrix interaction terms proved to be responsible for the best fit to data and to contribute to stress-strain nonlinearity. The mathematical model of tendon behavior developed in this study showed that fiber-matrix interactions are an important contributor to tendon behavior The more complete characterization of mechanical behavior afforded by this mathematical model can lead to an improved understanding of structure-function relationships in soft tissues and, ultimately, to the development of tissue-engineered therapies for injury or degeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0148-0731
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
345-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
The role of fiber-matrix interactions in a nonlinear fiber-reinforced strain energy model of tendon.
pubmed:affiliation
Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, 424 Stemmler Hall, Philadelphia, PA 19104-6081, USA.
pubmed:publicationType
Journal Article, Comparative Study, Evaluation Studies