Linked Life Data

15971338

Source:http://linkedlifedata.com/resource/pubmed/id/15971338

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-6-22
pubmed:abstractText
Absorbed dose is the fundamental quantity used to quantify the exposure of any biological system to ionizing radiation. However, the relationship between dose and biological effect is not unique but varies with fractionation and time factor(s), radiation quality and irradiation conditions. In radiation therapy, weighting factors are used to correlate absorbed dose and clinical effects when altering irradiation conditions, or for combining or comparing different technical modalities. For some well established therapy modalities (e.g. fractionated photon beam therapy), a general agreement on weighting factors has been reached: it is based on the linear-quadratic model. For neutron, proton or ion therapy, the differences in radiation quality are currently accounted for using a diversity of methods (almost hospital specific). This paper reviews the current approaches used for evaluating or selecting the weighting factors and their application in clinical practice. The weighting factors take account of the RBE and other factors, such as fractionation when needed. Harmonization of these approaches will facilitate the exchange of information within the radiation oncology community and between centres using different technical modalities. In any case, when reporting the treatments, absorbed dose and irradiation conditions should always be specified in addition to the weighting factor and the weighted dose.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0167-8140
pubmed:author
pubmed:issnType
Print
pubmed:volume
73 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S176-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
RBE and weighting of absorbed dose in ion-beam therapy.
pubmed:affiliation
Cliniques Universitaires St-Luc, Université Catholique de Louvain, Avenue Hippocrate,5469, 1200 Brussels, Belgium. wambersie@rbnt.ucl.ac.be
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't