Source:http://linkedlifedata.com/resource/pubmed/id/15970794
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2005-6-22
|
| pubmed:abstractText |
SULT1A1 is a phase II detoxification enzyme involved in the biotransformation of a wide variety of endogenous and exogenous phenolic compounds. Human platelet SULT1A1 enzymatic activity shows marked inter-individual variability and a common coding polymorphism, SULT1A1*1/*2, has been described that accounts for a proportion of this variability. We examined the 5'-flanking region of the SULT1A1 gene to determine if genetic variability in this portion of the gene influenced enzymatic activity. Direct sequencing revealed five common genetic polymorphisms (-624G>C, -396G>A, -358A>C, -341C>G and -294T>C) that were present at different allele frequencies in Caucasian, African-American and Chinese groups. Platelet SULT1A1 enzymatic activity was significantly correlated with individual promoter region polymorphisms and the associations were different between African-Americans and Caucasians. Haplotypes were constructed and platelet enzymatic activity according to haplotype was examined. The haplotypes were also significantly correlated with activity; haplotypes GAACT and GGACT (accounting for 13% and 5% of inter-individual variability in platelet activity, respectively) were important in Caucasians while haplotypes GAACC, GAACT and GGACC (accounting for 8%, 5% and 4% of variability) were significantly associated with activity in African-Americans. The coding region polymorphism, SULT1A1*1/*2 was in linkage disequilibrium with the promoter region polymorphisms and showed no effect on activity when examined in the context of the 5'-flanking region polymorphisms. These studies indicate that variation in the promoter region of the SULT1A1 gene exerts a significant influence on enzymatic activity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1744-6872
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| pubmed:author |
pubmed-author:AmbrosoneChristine BCB,
pubmed-author:KadlubarFred FFF,
pubmed-author:LangNicholas PNP,
pubmed-author:LiangGangG,
pubmed-author:LinDongxinD,
pubmed-author:ManjanathaMugimaneM,
pubmed-author:MiaoXiaopingX,
pubmed-author:NingBaitangB,
pubmed-author:NowellSusanS,
pubmed-author:RatnasingheD LukeDL,
pubmed-author:StoneAngieA,
pubmed-author:SweeneyCarolC,
pubmed-author:WilliamsSuzanneS
|
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
465-73
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15970794-5' Flanking Region,
pubmed-meshheading:15970794-Adult,
pubmed-meshheading:15970794-African Continental Ancestry Group,
pubmed-meshheading:15970794-Aged,
pubmed-meshheading:15970794-Aged, 80 and over,
pubmed-meshheading:15970794-Arylsulfotransferase,
pubmed-meshheading:15970794-Asian Continental Ancestry Group,
pubmed-meshheading:15970794-Blood Platelets,
pubmed-meshheading:15970794-Case-Control Studies,
pubmed-meshheading:15970794-Ethnic Groups,
pubmed-meshheading:15970794-European Continental Ancestry Group,
pubmed-meshheading:15970794-Female,
pubmed-meshheading:15970794-Genotype,
pubmed-meshheading:15970794-Haplotypes,
pubmed-meshheading:15970794-Humans,
pubmed-meshheading:15970794-Linkage Disequilibrium,
pubmed-meshheading:15970794-Male,
pubmed-meshheading:15970794-Middle Aged,
pubmed-meshheading:15970794-Polymerase Chain Reaction,
pubmed-meshheading:15970794-Polymorphism, Single Nucleotide
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Common genetic polymorphisms in the 5'-flanking region of the SULT1A1 gene: haplotypes and their association with platelet enzymatic activity.
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| pubmed:affiliation |
Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arizona, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.
|