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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
33
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pubmed:dateCreated |
2005-8-15
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pubmed:abstractText |
Type 2 diabetics have an increased risk of developing atherosclerosis, suggesting the mechanisms that cause this disease are enhanced by insulin resistance. In this study we examined the effects of gene knock-out (KO) of lipocalin-type prostaglandin D(2) synthase (L-PGDS), a protein found at elevated levels in type 2 diabetics, on diet-induced glucose tolerance and atherosclerosis. Our results show that L-PGDS KO mice become glucose-in-tolerant and insulin-resistant at an accelerated rate when compared with the C57BL/6 control strain. Adipocytes were significantly larger in the L-PGDS KO mice compared with controls on the same diets. Cell culture data revealed significant differences between insulin-stimulated mitogen-activated protein kinase phosphatase-2, protein-tyrosine phosphatase-1D, and phosphorylated focal adhesion kinase expression levels in L-PGDS KO vascular smooth muscle cells and controls. In addition, only the L-PGDS KO mice developed nephropathy and an aortic thickening reminiscent to the early stages of atherosclerosis when fed a "diabetogenic" high fat diet. We conclude that L-PGDS plays an important role regulating insulin sensitivity and atherosclerosis in type 2 diabetes and may represent a novel model of insulin resistance, atherosclerosis, and diabetic nephropathy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Protein-Tyrosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Intramolecular Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Lipocalins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Phosphatase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptk2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/prostaglandin R2 D-isomerase
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29946-55
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15970590-Adipocytes,
pubmed-meshheading:15970590-Adiponectin,
pubmed-meshheading:15970590-Animals,
pubmed-meshheading:15970590-Arteriosclerosis,
pubmed-meshheading:15970590-Blood Glucose,
pubmed-meshheading:15970590-Diabetic Nephropathies,
pubmed-meshheading:15970590-Focal Adhesion Kinase 1,
pubmed-meshheading:15970590-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:15970590-Glucose Intolerance,
pubmed-meshheading:15970590-Insulin,
pubmed-meshheading:15970590-Insulin Resistance,
pubmed-meshheading:15970590-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:15970590-Intramolecular Oxidoreductases,
pubmed-meshheading:15970590-Lipocalins,
pubmed-meshheading:15970590-Male,
pubmed-meshheading:15970590-Mice,
pubmed-meshheading:15970590-Mice, Inbred C57BL,
pubmed-meshheading:15970590-Mice, Knockout,
pubmed-meshheading:15970590-Protein Phosphatase 2,
pubmed-meshheading:15970590-Protein Tyrosine Phosphatases,
pubmed-meshheading:15970590-Protein-Tyrosine Kinases
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pubmed:year |
2005
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pubmed:articleTitle |
Accelerated glucose intolerance, nephropathy, and atherosclerosis in prostaglandin D2 synthase knock-out mice.
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pubmed:affiliation |
Vascular Biology Laboratory, Winthrop-University Hospital, Mineola, New York 11501, USA. lragolia@winthrop.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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