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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-6-21
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pubmed:abstractText |
We isolated and characterized the Xenopus translocon-associated protein XTRAP-gamma, one of four subunits of the translocon-associated protein complex. TRAP has been proposed to aid the translocation of nascent polypeptides into the lumen of the endoplasmic reticulum, but this has not been demonstrated until now. XTRAP-gamma was specifically expressed in the pronephros tubules of Xenopus laevis from stage 25 during kidney development. Antisense morpholino oligonucleotide-mediated knockdown of XTRAP-gamma suppressed tubulogenesis and decreased expression of the pronephros marker genes Pax-2 and Wnt-4. XTRAP-gamma morpholinos also inhibited differentiation of the pronephros in activin/retinoic acid-treated animal caps. We conclude that XTRAP-gamma plays an important role in the process of pronephros differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Activins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/signal sequence receptor
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pubmed:status |
MEDLINE
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pubmed:issn |
0214-6282
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
401-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15968585-Activins,
pubmed-meshheading:15968585-Amino Acid Sequence,
pubmed-meshheading:15968585-Animals,
pubmed-meshheading:15968585-Calcium-Binding Proteins,
pubmed-meshheading:15968585-Embryo, Nonmammalian,
pubmed-meshheading:15968585-Gene Expression Regulation, Developmental,
pubmed-meshheading:15968585-Gene Library,
pubmed-meshheading:15968585-Homeodomain Proteins,
pubmed-meshheading:15968585-In Situ Hybridization,
pubmed-meshheading:15968585-Inhibins,
pubmed-meshheading:15968585-Kidney,
pubmed-meshheading:15968585-Membrane Glycoproteins,
pubmed-meshheading:15968585-Molecular Sequence Data,
pubmed-meshheading:15968585-Oligonucleotides, Antisense,
pubmed-meshheading:15968585-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:15968585-Receptors, Peptide,
pubmed-meshheading:15968585-Up-Regulation,
pubmed-meshheading:15968585-Xenopus Proteins,
pubmed-meshheading:15968585-Xenopus laevis
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pubmed:year |
2005
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pubmed:articleTitle |
The role of XTRAP-gamma in Xenopus pronephros development.
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pubmed:affiliation |
Department of Pediatric Surgery and Oncology, Graduate School of Medicine, The University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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