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pubmed-article:15968248pubmed:abstractTextThe pathophysiology of acute pancreatitis is strongly associated with autoactivation of trypsin. The biologic activity of trypsin on cells is attributed to the activation of protease-activated receptor-2 (PAR-2). We hypothesize that trypsin may activate acinar cells or inflammatory cells through PAR-2 signals in acute pancreatitis.lld:pubmed
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pubmed-article:15968248pubmed:articleTitleProinflammatory role of trypsin and protease-activated receptor-2 in a rat model of acute pancreatitis.lld:pubmed
pubmed-article:15968248pubmed:affiliationDepartment of Gastroenterological Surgery, Postgraduate School of Medicine, Kumamoto University, Kumamoto-city, Kumamoto, Japan.lld:pubmed
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