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rdf:type |
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lifeskim:mentions |
umls-concept:C0003591,
umls-concept:C0010054,
umls-concept:C0018787,
umls-concept:C0026809,
umls-concept:C0027051,
umls-concept:C0074129,
umls-concept:C0277785,
umls-concept:C0332307,
umls-concept:C0456387,
umls-concept:C1855073,
umls-concept:C1947917
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pubmed:issue |
25
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pubmed:dateCreated |
2005-6-28
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pubmed:abstractText |
Normal chow (low fat)-fed mice deficient in both the HDL receptor SR-BI and apolipoprotein E (SR-BI/apoE dKO) provide a distinctive model of coronary heart disease (CHD). They exhibit early-onset hypercholesterolemia characterized by unesterified cholesterol-rich abnormal lipoproteins (lamellar/vesicular and stacked discoidal particles), occlusive coronary atherosclerosis, spontaneous myocardial infarction, cardiac dysfunction, and premature death ( approximately 6 weeks of age). Mice in which similar features of CHD could be induced with a lipid-rich diet would represent a powerful tool to study CHD.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4539
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3457-64
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15967843-Animals,
pubmed-meshheading:15967843-Apolipoproteins E,
pubmed-meshheading:15967843-Cardiomegaly,
pubmed-meshheading:15967843-Coronary Artery Disease,
pubmed-meshheading:15967843-Diet, Atherogenic,
pubmed-meshheading:15967843-Disease Models, Animal,
pubmed-meshheading:15967843-Electrocardiography,
pubmed-meshheading:15967843-Heart Diseases,
pubmed-meshheading:15967843-Heart Failure,
pubmed-meshheading:15967843-Hypercholesterolemia,
pubmed-meshheading:15967843-Lipids,
pubmed-meshheading:15967843-Mice,
pubmed-meshheading:15967843-Mice, Knockout,
pubmed-meshheading:15967843-Mortality,
pubmed-meshheading:15967843-Myocardial Infarction,
pubmed-meshheading:15967843-Scavenger Receptors, Class B
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pubmed:year |
2005
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pubmed:articleTitle |
Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice.
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pubmed:affiliation |
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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