Source:http://linkedlifedata.com/resource/pubmed/id/15967696
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2005-7-19
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pubmed:abstractText |
Glutathione peroxidases (GPxs) are a family of enzymes that scavenge peroxides generated in cells. We carried out molecular cloning for cDNAs of four GPx isozymes (GPx-1 through 4) in primate species. The essential residues for the function of these isozymes were well conserved. A phylogenetic tree of GPx isozymes of primates and other mammals showed that GPx-4 diverged first, followed by GPx-3, GPx-2, and GPx-1. Expression of mRNAs for GPx-2 through 4 in various tissues of Japanese monkey was analyzed by Northern blot hybridization. GPx-2 mRNA was detected at 1.7 kb, exclusively in the stomach and small intestine. GPx-3 mRNA was detected at 1.8 kb, intensively in the kidney and adrenal gland, and weakly in the cerebellum, heart, and lung. GPx-4 mRNA was detected at 1.1 kb, very intensively in the testis and weakly in lung, heart, and cerebellum. These results showed that GPx isozymes were expressed under tissue-specific regulations.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1096-4959
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
428-36
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15967696-Amino Acid Sequence,
pubmed-meshheading:15967696-Animals,
pubmed-meshheading:15967696-Cebus,
pubmed-meshheading:15967696-Cloning, Molecular,
pubmed-meshheading:15967696-DNA, Complementary,
pubmed-meshheading:15967696-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:15967696-Glutathione Peroxidase,
pubmed-meshheading:15967696-Humans,
pubmed-meshheading:15967696-Hylobates,
pubmed-meshheading:15967696-Isoenzymes,
pubmed-meshheading:15967696-Macaca,
pubmed-meshheading:15967696-Male,
pubmed-meshheading:15967696-Molecular Sequence Data,
pubmed-meshheading:15967696-Phylogeny,
pubmed-meshheading:15967696-Pongo pygmaeus,
pubmed-meshheading:15967696-RNA, Messenger,
pubmed-meshheading:15967696-Sequence Homology, Amino Acid,
pubmed-meshheading:15967696-Species Specificity
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pubmed:year |
2005
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pubmed:articleTitle |
Structure, gene expression, and evolution of primate glutathione peroxidases.
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pubmed:affiliation |
Center for Human Evolution Modeling Research, Primate Research Institute, Kyoto University, Inuyama Aichi, 484-8506, Japan. fukuhara@pri.kyoto-u.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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