Linked Life Data

1596755

Source:http://linkedlifedata.com/resource/pubmed/id/1596755

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-7-7
pubmed:abstractText
The effects of uncontrollable footshock were assessed in CD-1 mice responding for electrical brain stimulation (ICSS) from the dorsal aspects of the ventral tegmental area (VTA). Uncontrollable footshock provoked a marked reduction of responding for ICSS immediately, 24 h and 168 h following initial stressor exposure. Intraventricular administration of the neuropeptide, D-Ala2-Met5-enkephalinamide (DALA) (1 microgram/microliter delivered in a 1-microliter volume) following induction of reward alterations from the dorsal VTA provoked a rapid recovery of responding for ICSS in the immediate poststressor interval. This ameliorative effect of the neuropeptide deteriorated 24 h after initial exposure to uncontrollable footshock and was absent 1 week later. These data are discussed with respect to stressor-induced anhedonia in the mesocorticolimbic system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
337-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Intraventricular administration of D-Ala2-Met5-enkephalinamide induces rapid recovery of responding for electrical brain stimulation from the ventral tegmental area following uncontrollable footshock.
pubmed:affiliation
Psychology Department, Carleton University, Ottawa, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't