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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-7-11
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pubmed:abstractText |
Neuropathogenic murine antibodies reactive with terminal disialylgalactose epitopes are innate and preferentially encoded by the VH7183.3b gene. Here we have studied antibodies reactive with internal galactose-linked disialosyl epitopes and the terminal trisaccharide of GT1b. Antibodies were of moderate affinity and unmutated. Anti-GD1b antibodies were often encoded by the VH10.2b heavy and gj38c light chain genes. Anti-GT1b antibodies with broader glycan binding patterns were encoded by VHQ52 and VHJ558 family genes. These data indicate that the discrete specificities of ganglioside-binding antibodies are dictated by particular patterns of V gene usage residing within the innate B cell repertoire.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
92-103
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15967512-Amino Acid Sequence,
pubmed-meshheading:15967512-Animals,
pubmed-meshheading:15967512-Antibodies, Monoclonal,
pubmed-meshheading:15967512-Antibody Specificity,
pubmed-meshheading:15967512-Binding Sites, Antibody,
pubmed-meshheading:15967512-G(M1) Ganglioside,
pubmed-meshheading:15967512-Gangliosides,
pubmed-meshheading:15967512-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:15967512-Gene Rearrangement, B-Lymphocyte, Light Chain,
pubmed-meshheading:15967512-Immunoglobulin Variable Region,
pubmed-meshheading:15967512-Male,
pubmed-meshheading:15967512-Mice,
pubmed-meshheading:15967512-Mice, Inbred C57BL,
pubmed-meshheading:15967512-Mice, Knockout,
pubmed-meshheading:15967512-Molecular Sequence Data,
pubmed-meshheading:15967512-Sialyltransferases,
pubmed-meshheading:15967512-Surface Plasmon Resonance
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pubmed:year |
2005
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pubmed:articleTitle |
Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire.
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pubmed:affiliation |
University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland G51 4TF, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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