Linked Life Data

15965950

Source:http://linkedlifedata.com/resource/pubmed/id/15965950

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pubmed-article:15965950pubmed:dateCreated2005-11-3lld:pubmed
pubmed-article:15965950pubmed:abstractTextMany mammalian SWI/SNF complexes use Brahma-related gene 1 (Brg1) as a catalytic subunit to remodel nucleosomes for transcription regulation. In several mesenchymal cells and tissues, expression of a defective Brg1 protein negates the normal activity of the SWI/SNF complex and delays or blocks differentiation. To investigate the role of SWI/SNF complexes during myelopoiesis, we stably expressed a dominant negative (dn) Brg1 mutant in the myeloid lineage. Forced expression of dnBrg1 in IL-3-dependent murine 32Dcl3 myeloid progenitor cells results in a profound delay in the granulocyte-colony stimulating factor (G-CSF) induced granulocytic maturation. These cells also exhibit a significant decrease in the expression of both CD11b and Gr-1 surface receptors, which are normally upregulated during granulopoiesis, and show sustained expression of myeloperoxidase, which is synthesized primarily during the promyelocytic (blast) stage of myeloid development. Thus, dnBrg1 expression causes a developmental block at the promyelocytic/metamyelocytic stage of myeloid differentiation. Our findings indicate that the normal chromatin remodeling function of Brg1 is necessary for the G-CSF dependent differentiation of myeloid cells towards the granulocytic lineage. This dependency on Brg1 may reflect a stringent requirement for chromatin remodeling at a critical stage of hematopoietic cell maturation.lld:pubmed
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pubmed-article:15965950pubmed:copyrightInfoCopyright 2005 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:15965950pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:15965950pubmed:articleTitleBrg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes.lld:pubmed
pubmed-article:15965950pubmed:affiliationDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655-0106, USA.lld:pubmed
pubmed-article:15965950pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15965950pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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