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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
32
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pubmed:dateCreated |
2005-8-8
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pubmed:abstractText |
Chlamydia pneumoniae is the causative agent of respiratory tract infections and a number of chronic diseases. Here we investigated the involvement of the common TLR adaptor molecule MyD88 in host responses to C. pneumoniae-induced pneumonia in mice. MyD88-deficient mice were severely impaired in their ability to mount an acute early inflammatory response toward C. pneumoniae. Although the bacterial burden in the lungs was comparable 5 days after infection, MyD88-deficient mice exhibited only minor signs of pneumonia and reduced expression of inflammatory mediators. MyD88-deficient mice were unable to up-regulate proinflammatory cytokines and chemokines, demonstrated delayed recruitment of CD8+ and CD4+ T cells to the lungs, and were unable to clear the pathogen from their lungs at day 14. At day 14 the MyD88-deficent mice developed a severe, chronic lung inflammation with elevated IL-1beta and IFN-gamma leading to increased mortality, whereas wild-type mice as well as TLR2- or TLR4-deficient mice recovered from acute pneumonia and did not show delayed bacterial clearance. Thus, MyD88 is essential to recognize C. pneumoniae infection and initiate a prompt and effective immune host response against this organism leading to clearance of bacteria from infected lungs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Myd88 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9258
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pubmed:author |
pubmed-author:AlsabehRandaR,
pubmed-author:ArditiMosheM,
pubmed-author:BulutYoncaY,
pubmed-author:ChenShuangS,
pubmed-author:KUY CYC,
pubmed-author:MichelsenKathrin SKS,
pubmed-author:NaikiYoshikazuY,
pubmed-author:PetersonEllena MEM,
pubmed-author:SchröderNicolas W JNW,
pubmed-author:SlepenkinAnatolyA,
pubmed-author:WongMichelle HMH,
pubmed-author:ZhangWenxuanW
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29242-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15964841-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:15964841-Animals,
pubmed-meshheading:15964841-Antigens, Differentiation,
pubmed-meshheading:15964841-Body Weight,
pubmed-meshheading:15964841-Bone Marrow Cells,
pubmed-meshheading:15964841-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15964841-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15964841-Cell Separation,
pubmed-meshheading:15964841-Chlamydophila Infections,
pubmed-meshheading:15964841-Chlamydophila pneumoniae,
pubmed-meshheading:15964841-Cytokines,
pubmed-meshheading:15964841-Disease Models, Animal,
pubmed-meshheading:15964841-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15964841-Flow Cytometry,
pubmed-meshheading:15964841-Inflammation,
pubmed-meshheading:15964841-Lung,
pubmed-meshheading:15964841-Macrophages,
pubmed-meshheading:15964841-Mice,
pubmed-meshheading:15964841-Mice, Transgenic,
pubmed-meshheading:15964841-Myeloid Differentiation Factor 88,
pubmed-meshheading:15964841-Pneumonia, Bacterial,
pubmed-meshheading:15964841-Receptors, Immunologic,
pubmed-meshheading:15964841-Time Factors,
pubmed-meshheading:15964841-Toll-Like Receptor 2,
pubmed-meshheading:15964841-Toll-Like Receptor 4,
pubmed-meshheading:15964841-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
MyD88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of Chlamydia pneumoniae pneumonia.
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pubmed:affiliation |
Division of Pediatrics Infectious Diseases and Immunology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90048, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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