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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-6-20
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pubmed:abstractText |
In mitosis, a mechanochemical system recognizes tension that is generated by bipolar microtubule attachment to sister kinetochores. This is translated into multiple outputs including the stabilization of microtubule attachments, changes in kinetochore protein dynamics, and the silencing of the spindle checkpoint. How kinetochores sense tension and translate this into various signals represent critical unanswered questions. The kinetochores of chromosomes not under tension are specifically phosphorylated at an epitope recognized by the 3F3/2 monoclonal antibody. Determining the kinase that generates the 3F3/2 phosphoepitope at kinetochores should reveal an important component of this system that regulates mitotic progression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Cdc20 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Mad2l1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Mad2l2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NDC80 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/SPC24 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/centromere protein E,
http://linkedlifedata.com/resource/pubmed/chemical/polo-like kinase 1
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1078-89
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:15964272-Amino Acid Motifs,
pubmed-meshheading:15964272-Animals,
pubmed-meshheading:15964272-Antibodies, Monoclonal,
pubmed-meshheading:15964272-Cell Cycle Proteins,
pubmed-meshheading:15964272-Cells, Cultured,
pubmed-meshheading:15964272-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:15964272-Epitopes,
pubmed-meshheading:15964272-HeLa Cells,
pubmed-meshheading:15964272-Humans,
pubmed-meshheading:15964272-Kinetochores,
pubmed-meshheading:15964272-Microtubule-Associated Proteins,
pubmed-meshheading:15964272-Mitosis,
pubmed-meshheading:15964272-Mitotic Spindle Apparatus,
pubmed-meshheading:15964272-Nuclear Proteins,
pubmed-meshheading:15964272-Phosphorylation,
pubmed-meshheading:15964272-Protein Kinases,
pubmed-meshheading:15964272-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15964272-Proteins,
pubmed-meshheading:15964272-Proto-Oncogene Proteins,
pubmed-meshheading:15964272-RNA, Small Interfering,
pubmed-meshheading:15964272-Xenopus
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pubmed:year |
2005
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pubmed:articleTitle |
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores.
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pubmed:affiliation |
Molecular, Cell and Developmental Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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