Source:http://linkedlifedata.com/resource/pubmed/id/15964195
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
|
| pubmed:dateCreated |
2005-8-22
|
| pubmed:abstractText |
The potential of novel and known pyridyl thiourea derivatives (non-nucleoside inhibitors (NNI) of HIV reverse transcriptase) as bifunctional organic catalysts in the asymmetric Strecker synthesis was investigated. It was shown that incorporation of the imidazolyl moiety in place of a pyridyl group results in a new thiourea derivative that displays a much higher catalytic activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0968-0896
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5680-5
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15964195-Catalysis,
pubmed-meshheading:15964195-Crystallography, X-Ray,
pubmed-meshheading:15964195-HIV,
pubmed-meshheading:15964195-HIV Reverse Transcriptase,
pubmed-meshheading:15964195-Models, Molecular,
pubmed-meshheading:15964195-Molecular Structure,
pubmed-meshheading:15964195-Reverse Transcriptase Inhibitors,
pubmed-meshheading:15964195-Stereoisomerism,
pubmed-meshheading:15964195-Structure-Activity Relationship,
pubmed-meshheading:15964195-Thiourea
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Thiourea-based non-nucleoside inhibitors of HIV reverse transcriptase as bifunctional organocatalysts in the asymmetric Strecker synthesis.
|
| pubmed:affiliation |
Institut für Organische und Biomolekulare Chemie der Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany. stsogoe@gwdg.de
|
| pubmed:publicationType |
Journal Article
|