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rdf:type |
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lifeskim:mentions |
umls-concept:C0018270,
umls-concept:C0237477,
umls-concept:C0243125,
umls-concept:C0598086,
umls-concept:C0598388,
umls-concept:C0699900,
umls-concept:C0752313,
umls-concept:C1415887,
umls-concept:C1419040,
umls-concept:C1420433,
umls-concept:C1424666,
umls-concept:C1510411,
umls-concept:C1533157,
umls-concept:C1704259,
umls-concept:C1705987
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pubmed:issue |
7
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pubmed:dateCreated |
2005-6-20
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pubmed:abstractText |
To examine whether oncogenic Ras affects transforming growth factor (TGF)-beta-mediated cell-cycle arrest in hematopoietic cells and the downstream signal transduction pathway involved in the interference with TGF-beta-induced cell-cycle arrest.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/S-Phase Kinase-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
747-57
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15963850-Animals,
pubmed-meshheading:15963850-Base Sequence,
pubmed-meshheading:15963850-Cell Cycle,
pubmed-meshheading:15963850-Cell Cycle Proteins,
pubmed-meshheading:15963850-Cell Line, Tumor,
pubmed-meshheading:15963850-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:15963850-DNA Mutational Analysis,
pubmed-meshheading:15963850-Electroporation,
pubmed-meshheading:15963850-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:15963850-Flow Cytometry,
pubmed-meshheading:15963850-Genes, ras,
pubmed-meshheading:15963850-HL-60 Cells,
pubmed-meshheading:15963850-Humans,
pubmed-meshheading:15963850-Mice,
pubmed-meshheading:15963850-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:15963850-RNA Interference,
pubmed-meshheading:15963850-Recombinant Proteins,
pubmed-meshheading:15963850-S-Phase Kinase-Associated Proteins,
pubmed-meshheading:15963850-Signal Transduction,
pubmed-meshheading:15963850-Transfection,
pubmed-meshheading:15963850-Transforming Growth Factor beta,
pubmed-meshheading:15963850-Tumor Suppressor Proteins,
pubmed-meshheading:15963850-ras Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway.
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pubmed:affiliation |
Division of Hematology, Department of Medicine, University Medical Center Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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