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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-7-8
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pubmed:abstractText |
Vascular enlargement is a characteristic feature of angiopoietin-1 (Ang1)-induced changes in adult blood vessels. However, it is unknown whether tissues having Ang1-mediated vascular enlargement have more blood flow or whether the enlargement is reversible. We have recently created a soluble, stable and potent Ang1 variant, COMP-Ang1. In the present study, we investigated the effects of varied dose and duration of COMP-Ang1 on vascular enlargement and blood flow in the tracheal microvasculature of adult mice and explored a possible mechanism of long-lasting vascular enlargement. We found that COMP-Ang1 administered by adenoviral vector induced long-lasting vascular enlargement and increased tracheal blood flow. In contrast, short-term administration of COMP-Ang1 recombinant protein induced transient vascular enlargement that spontaneously reversed within a month. In both cases, the vascular enlargement resulted from endothelial proliferation. The COMP-Ang1-induced vascular remodeling is mediated mainly through Tie2 activation. Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4571
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pubmed:author |
pubmed-author:BaffertFabienneF,
pubmed-author:BalukPeterP,
pubmed-author:ByunJonghoeJ,
pubmed-author:ChoChung-HyunCH,
pubmed-author:JangHyung-SukHS,
pubmed-author:JeonByeong HwaBH,
pubmed-author:KayL WLW,
pubmed-author:KimDuk-KyungDK,
pubmed-author:KimKyung EunKE,
pubmed-author:KohGou YoungGY,
pubmed-author:LeeGyun MinGM,
pubmed-author:McDonaldDonald MDM,
pubmed-author:MochizukiNaokiN
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
86-94
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15961719-Adenoviridae,
pubmed-meshheading:15961719-Angiopoietin-1,
pubmed-meshheading:15961719-Animals,
pubmed-meshheading:15961719-Arterioles,
pubmed-meshheading:15961719-Blood Vessels,
pubmed-meshheading:15961719-CHO Cells,
pubmed-meshheading:15961719-Cell Proliferation,
pubmed-meshheading:15961719-Cricetinae,
pubmed-meshheading:15961719-Endothelial Cells,
pubmed-meshheading:15961719-Extracellular Matrix Proteins,
pubmed-meshheading:15961719-Glycoproteins,
pubmed-meshheading:15961719-Male,
pubmed-meshheading:15961719-Mice,
pubmed-meshheading:15961719-Mice, Transgenic,
pubmed-meshheading:15961719-Receptor, TIE-2,
pubmed-meshheading:15961719-Recombinant Proteins,
pubmed-meshheading:15961719-Regional Blood Flow,
pubmed-meshheading:15961719-Trachea,
pubmed-meshheading:15961719-Venules
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pubmed:year |
2005
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pubmed:articleTitle |
Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow.
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pubmed:affiliation |
Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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