Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-6-24
pubmed:abstractText
Suramin, a synthetic polysulfonated compound, developed initially for the treatment of African trypanosomiasis and onchocerciasis, is currently used for the treatment of several medically relevant disorders. Suramin, heparin, and other polyanions inhibit the myotoxic activity of Lys49 phospholipase A2 analogues both in vitro and in vivo, and are thus of potential importance as therapeutic agents in the treatment of viperid snake bites. Due to its conformational flexibility around the single bonds that link the central phenyl rings to the secondary amide backbone, the symmetrical suramin molecule binds by an induced-fit mechanism complementing the hydrophobic surfaces of the dimer and adopts a novel conformation that lacks C2 symmetry in the dimeric crystal structure of the suramin-Bothrops asper myotoxin II complex. The simultaneous binding of suramin at the surfaces of the two monomers partially restricts access to the nominal active sites and significantly changes the overall charge of the interfacial recognition face of the protein, resulting in the inhibition of myotoxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Anions, http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/Group II Phospholipases A2, http://linkedlifedata.com/resource/pubmed/chemical/Heparin, http://linkedlifedata.com/resource/pubmed/chemical/Lysine, http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins, http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases A, http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases A2, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Reptilian Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Suramin, http://linkedlifedata.com/resource/pubmed/chemical/Trypanocidal Agents, http://linkedlifedata.com/resource/pubmed/chemical/myotoxin II, Bothrops asper
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-2836
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
350
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
416-26
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15961104-Animals, pubmed-meshheading:15961104-Anions, pubmed-meshheading:15961104-Binding Sites, pubmed-meshheading:15961104-Bothrops, pubmed-meshheading:15961104-Calcium, pubmed-meshheading:15961104-Catalysis, pubmed-meshheading:15961104-Chromatography, Ion Exchange, pubmed-meshheading:15961104-Crystallization, pubmed-meshheading:15961104-Crystallography, X-Ray, pubmed-meshheading:15961104-Databases, Protein, pubmed-meshheading:15961104-Electrons, pubmed-meshheading:15961104-Group II Phospholipases A2, pubmed-meshheading:15961104-Heparin, pubmed-meshheading:15961104-Lysine, pubmed-meshheading:15961104-Magnetic Resonance Spectroscopy, pubmed-meshheading:15961104-Mice, pubmed-meshheading:15961104-Models, Chemical, pubmed-meshheading:15961104-Models, Molecular, pubmed-meshheading:15961104-Molecular Conformation, pubmed-meshheading:15961104-Muscles, pubmed-meshheading:15961104-Neurotoxins, pubmed-meshheading:15961104-Phospholipases A, pubmed-meshheading:15961104-Phospholipases A2, pubmed-meshheading:15961104-Protein Binding, pubmed-meshheading:15961104-Protein Conformation, pubmed-meshheading:15961104-Protein Structure, Tertiary, pubmed-meshheading:15961104-Proteins, pubmed-meshheading:15961104-Reptilian Proteins, pubmed-meshheading:15961104-Suramin, pubmed-meshheading:15961104-Trypanocidal Agents
pubmed:year
2005
pubmed:articleTitle
Inhibition of myotoxic activity of Bothrops asper myotoxin II by the anti-trypanosomal drug suramin.
pubmed:affiliation
Departament of Physics, IBILCE/UNESP, São José do Rio Preto, SP, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't