Source:http://linkedlifedata.com/resource/pubmed/id/15960497
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
13
|
| pubmed:dateCreated |
2005-6-17
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| pubmed:abstractText |
Chiral N-Tfa- and N-Fmoc-protected (alpha-aminoacyl)benzotriazoles 1a-j undergo Friedel-Crafts-type reactions with indole, N-methylindole, pyrrole, N-methylpyrrole, and benzene in the presence of AlCl(3) in efficient two-step sequences leading to enantiomerically pure alpha-amino N-heterocyclic ketones 2, 3, 5, 6, and 7 or diketone 4. In the absence of a reactive partner, Phe- and Trp-derivatives 1a, 1d undergo intramolecular cyclization to afford 12 and 13, again with retention of chirality.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-3263
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
24
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| pubmed:volume |
70
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4993-5000
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| pubmed:year |
2005
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| pubmed:articleTitle |
N-Tfa- and N-Fmoc-(alpha-aminoacyl)benzotriazoles as chiral C-acylating reagents under Friedel-Crafts reaction conditions.
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| pubmed:affiliation |
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
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| pubmed:publicationType |
Journal Article
|