Linked Life Data

15958781

Source:http://linkedlifedata.com/resource/pubmed/id/15958781

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-2-3
pubmed:abstractText
New granule neurons are produced in the dentate gyrus (DG) of rodents throughout adult life. Recent studies have also reported adult neurogenesis in the cerebral cortex in normal animals or after brain injury. However, few of these studies focused on the hippocampal formation (HF), a cortical area involved in learning and memory in which extensive cell death occurs in neurodegenerative diseases. Thus, we studied cell proliferation in the HF of rodents and the intrinsic putative neurogenic potential of entorhinal cortex (EC) progenitors. We show that only the DG generates new neurons in the HF. In addition, neurospheres from the EC differentiate into neurons and glia in vitro and after transplantation in the adult DG. We also analyzed whether the absence of the synaptic input from the main hippocampal afferents induces neuronal generation in the HF outside the DG and/or regulates the proliferation of DG neuroprogenitors. We show that the denervation of the hippocampus does not induce neurogenesis in HF regions other than the DG. However, neuroprogenitor proliferation in the DG is reduced after fimbria-fornix lesions but not after entorhinal deafferentation, which supports the view that neuroprogenitor proliferation and/or differentiation in the DG are controlled from basal forebrain/septal neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1047-3211
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-12
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Cell proliferation in the adult hippocampal formation of rodents and its modulation by entorhinal and fimbria-fornix afferents.
pubmed:affiliation
Development and Regeneration of the CNS, Department of Cell Biology, Barcelona Science Park-IRB, University of Barcelona, E-08028 Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't