| pubmed-article:15958077 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15958077 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:15958077 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15958077 | lifeskim:mentions | umls-concept:C0011603 | lld:lifeskim |
| pubmed-article:15958077 | lifeskim:mentions | umls-concept:C0011615 | lld:lifeskim |
| pubmed-article:15958077 | lifeskim:mentions | umls-concept:C0039082 | lld:lifeskim |
| pubmed-article:15958077 | lifeskim:mentions | umls-concept:C0700624 | lld:lifeskim |
| pubmed-article:15958077 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:15958077 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:15958077 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
| pubmed-article:15958077 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15958077 | pubmed:dateCreated | 2005-6-16 | lld:pubmed |
| pubmed-article:15958077 | pubmed:abstractText | Recent studies have suggested that not only alphabeta(+) T cells, but also the less common gammadelta(+) T cells may play a role as effectors and immunoregolatory cells in the development and perpetuation of allergic inflammation. The objective of this study was to focus on the role of gammadelta(+) T cells in atopic dermatitis (AD), a chronic relapsing inflammatory disease of the skin, often associated with allergic bronchial asthma. The present study employed flow cytometric analysis to compare numbers and phenotypic characteristics of gammadelta(+) T cells in the peripheral blood of children with atopic dermatitis and age-matched healthy controls. The percentage of circulating Vgamma 9Vdelta2(+) T lymphocytes was significantly increased in AD patients with respect to the age-matched controls, with a positive correlation with clinical score severity. The prevalent phenotype in both AD patients and controls was CD45RO(+), with no differences observed in the percentage of Vdelta2(+) CD45RO(+) between these groups. Conversely, memory CD45RO(+) CD62L(+) Vdelta2(+) lymphocytes were significantly lower in AD patients. Furthermore, naive circulating Vdelta2(+) T lymphocytes were significantly lower in AD children than in aged-matched controls. No correlation was observed between circulating Vgamma 9Vdelta2(+) expansion and IgE serum levels. It was concluded that an association exists between the levels of circulating gammadelta(+) T lymphocytes and atopic dermatitis, with a positive correlation with clinical score but no link with IgE serum levels. The pathophysiological role of gammadelta T lymphocytes in atopic dermatitis awaits further investigation. | lld:pubmed |
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| pubmed-article:15958077 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15958077 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15958077 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15958077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15958077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15958077 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15958077 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15958077 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:15958077 | pubmed:author | pubmed-author:GalliEE | lld:pubmed |
| pubmed-article:15958077 | pubmed:author | pubmed-author:BrunettiEE | lld:pubmed |
| pubmed-article:15958077 | pubmed:author | pubmed-author:MancinoGG | lld:pubmed |
| pubmed-article:15958077 | pubmed:author | pubmed-author:LandiFF | lld:pubmed |
| pubmed-article:15958077 | pubmed:author | pubmed-author:CasatiAA | lld:pubmed |
| pubmed-article:15958077 | pubmed:author | pubmed-author:CairoCC | lld:pubmed |
| pubmed-article:15958077 | pubmed:author | pubmed-author:ArabitoEE | lld:pubmed |
| pubmed-article:15958077 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15958077 | pubmed:volume | 141 | lld:pubmed |
| pubmed-article:15958077 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15958077 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15958077 | pubmed:pagination | 116-21 | lld:pubmed |
| pubmed-article:15958077 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15958077 | pubmed:meshHeading | pubmed-meshheading:15958077... | lld:pubmed |
| pubmed-article:15958077 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15958077 | pubmed:articleTitle | Analysis of circulating gammadelta T cells in children affected by IgE-associated and non-IgE-associated allergic atopic eczema/dermatitis syndrome. | lld:pubmed |
| pubmed-article:15958077 | pubmed:affiliation | Research Center San Pietro Hospital, Fatebenefratelli- AFaR- Rome, Italy. | lld:pubmed |
| pubmed-article:15958077 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15958077 | lld:pubmed |
