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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-6-16
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pubmed:abstractText |
Recent studies have suggested that not only alphabeta(+) T cells, but also the less common gammadelta(+) T cells may play a role as effectors and immunoregolatory cells in the development and perpetuation of allergic inflammation. The objective of this study was to focus on the role of gammadelta(+) T cells in atopic dermatitis (AD), a chronic relapsing inflammatory disease of the skin, often associated with allergic bronchial asthma. The present study employed flow cytometric analysis to compare numbers and phenotypic characteristics of gammadelta(+) T cells in the peripheral blood of children with atopic dermatitis and age-matched healthy controls. The percentage of circulating Vgamma 9Vdelta2(+) T lymphocytes was significantly increased in AD patients with respect to the age-matched controls, with a positive correlation with clinical score severity. The prevalent phenotype in both AD patients and controls was CD45RO(+), with no differences observed in the percentage of Vdelta2(+) CD45RO(+) between these groups. Conversely, memory CD45RO(+) CD62L(+) Vdelta2(+) lymphocytes were significantly lower in AD patients. Furthermore, naive circulating Vdelta2(+) T lymphocytes were significantly lower in AD children than in aged-matched controls. No correlation was observed between circulating Vgamma 9Vdelta2(+) expansion and IgE serum levels. It was concluded that an association exists between the levels of circulating gammadelta(+) T lymphocytes and atopic dermatitis, with a positive correlation with clinical score but no link with IgE serum levels. The pathophysiological role of gammadelta T lymphocytes in atopic dermatitis awaits further investigation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-10438380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-10502810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-10502818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-10582732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-10691888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-10719286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-10753009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-10808164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-11174205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-11290341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-11359378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-11551248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-11801693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-12052810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-12470608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-12519308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-12562394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-12699407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-13679813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-13679814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-2526644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-2572670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-7560632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-7665983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-8112855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-8435513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-8630617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-8729666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-9018970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-9072997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-9378958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-9465484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-9550399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-9596580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15958077-9989804
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
116-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15958077-Child,
pubmed-meshheading:15958077-Child, Preschool,
pubmed-meshheading:15958077-Dermatitis, Atopic,
pubmed-meshheading:15958077-Female,
pubmed-meshheading:15958077-Flow Cytometry,
pubmed-meshheading:15958077-Humans,
pubmed-meshheading:15958077-Immunoglobulin E,
pubmed-meshheading:15958077-Immunophenotyping,
pubmed-meshheading:15958077-Infant,
pubmed-meshheading:15958077-Male,
pubmed-meshheading:15958077-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:15958077-Severity of Illness Index,
pubmed-meshheading:15958077-Syndrome,
pubmed-meshheading:15958077-T-Lymphocyte Subsets
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pubmed:year |
2005
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pubmed:articleTitle |
Analysis of circulating gammadelta T cells in children affected by IgE-associated and non-IgE-associated allergic atopic eczema/dermatitis syndrome.
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pubmed:affiliation |
Research Center San Pietro Hospital, Fatebenefratelli- AFaR- Rome, Italy.
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pubmed:publicationType |
Journal Article
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