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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2005-6-16
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pubmed:abstractText |
[structure: see text] The total synthesis of FR235222, a potent immunosuppressant with in vivo activities, has been achieved. The key steps include assembling its (2S,9R)-2-amino-9-hydroxy-8-oxodecanoic acid residue via an olefin cross-metathesis of a methyl (R)-lactate-derived homoallyl ketone with protected allyl amino acid and constructing its trans-(2R,4S)-4-methylproline unit from protected (R)-pyroglutamic acid in seven steps.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1523-7060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2775-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15957944-Acremonium,
pubmed-meshheading:15957944-Animals,
pubmed-meshheading:15957944-Enzyme Inhibitors,
pubmed-meshheading:15957944-Histone Deacetylase Inhibitors,
pubmed-meshheading:15957944-Immunosuppressive Agents,
pubmed-meshheading:15957944-Mice,
pubmed-meshheading:15957944-Molecular Structure,
pubmed-meshheading:15957944-Peptides, Cyclic,
pubmed-meshheading:15957944-Pyrrolidonecarboxylic Acid,
pubmed-meshheading:15957944-Stereoisomerism,
pubmed-meshheading:15957944-Structure-Activity Relationship
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pubmed:year |
2005
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pubmed:articleTitle |
Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases.
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pubmed:affiliation |
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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