Linked Life Data

15955533

Source:http://linkedlifedata.com/resource/pubmed/id/15955533

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-9-9
pubmed:abstractText
The tumor suppressor candidate, inhibitor of growth (ING) is implicated in the control of apoptosis, cell cycle progression, chemosensitivity, and senescence. There are at least five different genes in mammals, ING1-ING5, and there is limited evidence that multiple transcript variants exist for ING1 that encode proteins with different functions. No variants have yet been reported for other ING genes. Here, we report the isolation of seven Xenopus laevis (x)ING1 and three xING2 transcript variants and give the first evidence for their independent regulation by thyroid hormone (TH). Comparison with mammalian genes reveals conservation in gene structure. xING1 and xING2 transcript variants are differentially expressed in adult tissues with the greatest number of variants expressed at high levels in brain, testis, and eye. During metamorphosis of the tadpole into a frog, the hindlimb, tail, and brain undergo growth, apoptosis, or remodeling, respectively. We show that xING1 and xING2 transcript variants are significantly reduced in the hindlimb while many variants increase in the tail. These transcript variants remain largely unchanged in the brain during this developmental period. By exposing premetamorphic tadpoles to TH, a precocious metamorphosis is induced. We identify specific variants whose steady state levels are significantly affected by TH at 24 and 48h of exposure. Although several of the variants show expression patterns reminiscent of that observed in natural metamorphosis, the results indicate that additional factors may be involved to influence the steady state transcript levels during development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0016-6480
pubmed:author
pubmed:issnType
Print
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15955533-Animals, pubmed-meshheading:15955533-Apoptosis, pubmed-meshheading:15955533-Base Sequence, pubmed-meshheading:15955533-Brain, pubmed-meshheading:15955533-Cell Cycle Proteins, pubmed-meshheading:15955533-Cell Proliferation, pubmed-meshheading:15955533-DNA-Binding Proteins, pubmed-meshheading:15955533-Gene Expression Regulation, pubmed-meshheading:15955533-Genes, Tumor Suppressor, pubmed-meshheading:15955533-Homeodomain Proteins, pubmed-meshheading:15955533-Larva, pubmed-meshheading:15955533-Molecular Sequence Data, pubmed-meshheading:15955533-Protein Isoforms, pubmed-meshheading:15955533-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:15955533-Sequence Alignment, pubmed-meshheading:15955533-Sequence Homology, Nucleic Acid, pubmed-meshheading:15955533-Thyroid Hormones, pubmed-meshheading:15955533-Tumor Suppressor Proteins, pubmed-meshheading:15955533-Xenopus Proteins, pubmed-meshheading:15955533-Xenopus laevis
pubmed:year
2005
pubmed:articleTitle
Multiple variants of the ING1 and ING2 tumor suppressors are differentially expressed and thyroid hormone-responsive in Xenopus laevis.
pubmed:affiliation
Department of Biochemistry and Microbiology, University of Victoria, P.O. Box 3055, Victoria, BC, Canada V8W 3P6.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't