rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-6-14
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pubmed:abstractText |
Myelodysplastic syndrome (MDS) progresses into acute leukaemia with a variable time course. We analysed 45 newly diagnosed patients and found that the expression of the Src homology 2 domain-containing tyrosine phosphatase 1 (SHP1) had a significant impact on disease severity, progression and overall prognosis. Global or lineage-specific loss of SHP1 was observed by immunohistochemistry in bone marrow biopsies of MDS patients who progressed rapidly (P = 0.0021) and had shorter survival (P < 0.001). Cox regression analysis demonstrated that SHP1 expression in megakaryocytes had prognostic relevance for time to progression (P = 0.009) and overall survival (P = 0.001).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
0007-1048
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pubmed:author |
pubmed-author:BazhenovaLyudmilaL,
pubmed-author:BethelKellyK,
pubmed-author:CerveraJoseJ,
pubmed-author:Mena-DuranArmando VAV,
pubmed-author:MustelinTomasT,
pubmed-author:NievaJorgeJ,
pubmed-author:SanzGuillermo FGF,
pubmed-author:SanzMiguel AMA,
pubmed-author:SavenAlanA,
pubmed-author:SenentMaria LML,
pubmed-author:TogoSummanuna HSH
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pubmed:issnType |
Print
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
791-4
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15953006-Adult,
pubmed-meshheading:15953006-Aged,
pubmed-meshheading:15953006-Aged, 80 and over,
pubmed-meshheading:15953006-Biological Markers,
pubmed-meshheading:15953006-Biopsy,
pubmed-meshheading:15953006-Bone Marrow,
pubmed-meshheading:15953006-Disease Progression,
pubmed-meshheading:15953006-Female,
pubmed-meshheading:15953006-Humans,
pubmed-meshheading:15953006-Immunoenzyme Techniques,
pubmed-meshheading:15953006-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15953006-Male,
pubmed-meshheading:15953006-Middle Aged,
pubmed-meshheading:15953006-Myelodysplastic Syndromes,
pubmed-meshheading:15953006-Prognosis,
pubmed-meshheading:15953006-Protein Phosphatase 1,
pubmed-meshheading:15953006-Protein Tyrosine Phosphatase, Non-Receptor Type 6,
pubmed-meshheading:15953006-Protein Tyrosine Phosphatases,
pubmed-meshheading:15953006-Survival Analysis
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pubmed:year |
2005
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pubmed:articleTitle |
SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic factor.
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pubmed:affiliation |
Inflammatory and Infectious Disease Center, The Burnham Institute, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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