Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-6-14
pubmed:abstractText
Myelodysplastic syndrome (MDS) progresses into acute leukaemia with a variable time course. We analysed 45 newly diagnosed patients and found that the expression of the Src homology 2 domain-containing tyrosine phosphatase 1 (SHP1) had a significant impact on disease severity, progression and overall prognosis. Global or lineage-specific loss of SHP1 was observed by immunohistochemistry in bone marrow biopsies of MDS patients who progressed rapidly (P = 0.0021) and had shorter survival (P < 0.001). Cox regression analysis demonstrated that SHP1 expression in megakaryocytes had prognostic relevance for time to progression (P = 0.009) and overall survival (P = 0.001).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-1048
pubmed:author
pubmed:issnType
Print
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
791-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15953006-Adult, pubmed-meshheading:15953006-Aged, pubmed-meshheading:15953006-Aged, 80 and over, pubmed-meshheading:15953006-Biological Markers, pubmed-meshheading:15953006-Biopsy, pubmed-meshheading:15953006-Bone Marrow, pubmed-meshheading:15953006-Disease Progression, pubmed-meshheading:15953006-Female, pubmed-meshheading:15953006-Humans, pubmed-meshheading:15953006-Immunoenzyme Techniques, pubmed-meshheading:15953006-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:15953006-Male, pubmed-meshheading:15953006-Middle Aged, pubmed-meshheading:15953006-Myelodysplastic Syndromes, pubmed-meshheading:15953006-Prognosis, pubmed-meshheading:15953006-Protein Phosphatase 1, pubmed-meshheading:15953006-Protein Tyrosine Phosphatase, Non-Receptor Type 6, pubmed-meshheading:15953006-Protein Tyrosine Phosphatases, pubmed-meshheading:15953006-Survival Analysis
pubmed:year
2005
pubmed:articleTitle
SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic factor.
pubmed:affiliation
Inflammatory and Infectious Disease Center, The Burnham Institute, La Jolla, CA 92037, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural