|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2005-6-13
|
|
pubmed:abstractText |
Epidermal growth factor receptor (EGFR) exists in the nucleus of highly proliferative cells where it functions as a transcription factor. Although EGFR has transactivational activity, it lacks a DNA binding domain and, therefore, may require a DNA binding transcription cofactor for its transcriptional function. Here, we report that EGFR physically interacts with signal transducers and activators of transcription 3 (STAT3) in the nucleus, leading to transcriptional activation of inducible nitric oxide synthase (iNOS). In breast carcinomas, nuclear EGFR positively correlates with iNOS. This study describes a mode of transcriptional control involving cooperated efforts of STAT3 and nuclear EGFR. Our work suggests that the deregulated iNOS/NO pathway may partly contribute to the malignant biology of tumor cells with high levels of nuclear EGFR and STAT3.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/S-Nitroso-N-Acetylpenicillamine,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1535-6108
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
575-89
|
|
pubmed:dateRevised |
2011-10-27
|
|
pubmed:meshHeading |
pubmed-meshheading:15950906-Animals,
pubmed-meshheading:15950906-Base Sequence,
pubmed-meshheading:15950906-Binding Sites,
pubmed-meshheading:15950906-Breast Neoplasms,
pubmed-meshheading:15950906-CHO Cells,
pubmed-meshheading:15950906-Cell Line, Tumor,
pubmed-meshheading:15950906-Cell Nucleus,
pubmed-meshheading:15950906-Cell Survival,
pubmed-meshheading:15950906-Chromatin Immunoprecipitation,
pubmed-meshheading:15950906-Cricetinae,
pubmed-meshheading:15950906-Cricetulus,
pubmed-meshheading:15950906-DNA-Binding Proteins,
pubmed-meshheading:15950906-Drug Synergism,
pubmed-meshheading:15950906-Epidermal Growth Factor,
pubmed-meshheading:15950906-Female,
pubmed-meshheading:15950906-Gene Expression,
pubmed-meshheading:15950906-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15950906-Genes, bcl-1,
pubmed-meshheading:15950906-Genes, fos,
pubmed-meshheading:15950906-HeLa Cells,
pubmed-meshheading:15950906-Humans,
pubmed-meshheading:15950906-Janus Kinase 2,
pubmed-meshheading:15950906-Microscopy, Fluorescence,
pubmed-meshheading:15950906-Microscopy, Immunoelectron,
pubmed-meshheading:15950906-Nitric Oxide,
pubmed-meshheading:15950906-Nitric Oxide Synthase,
pubmed-meshheading:15950906-Nitric Oxide Synthase Type II,
pubmed-meshheading:15950906-Phosphorylation,
pubmed-meshheading:15950906-Prognosis,
pubmed-meshheading:15950906-Promoter Regions, Genetic,
pubmed-meshheading:15950906-Protein Binding,
pubmed-meshheading:15950906-Protein Kinase Inhibitors,
pubmed-meshheading:15950906-Protein-Tyrosine Kinases,
pubmed-meshheading:15950906-Proto-Oncogene Proteins,
pubmed-meshheading:15950906-Receptor, Epidermal Growth Factor,
pubmed-meshheading:15950906-S-Nitroso-N-Acetylpenicillamine,
pubmed-meshheading:15950906-STAT3 Transcription Factor,
pubmed-meshheading:15950906-Signal Transduction,
pubmed-meshheading:15950906-Survival Analysis,
pubmed-meshheading:15950906-Trans-Activators
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
